Epsilon toxin–producing Clostridium perfringens colonize the multiple sclerosis gut microbiome overcoming CNS immune privilege

Multiple sclerosis (MS) is a complex disease of the CNS thought to require an environmental trigger. Gut dysbiosis is common in MS, but specific causative species are unknown. To address this knowledge gap, we used sensitive and quantitative PCR detection to show that people with MS were more likely...

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Detalles Bibliográficos
Autores principales: Ma, Yinghua, Sannino, David, Linden, Jennifer R., Haigh, Sylvia, Zhao, Baohua, Grigg, John B., Zumbo, Paul, Dündar, Friederike, Butler, Daniel, Profaci, Caterina P., Telesford, Kiel, Winokur, Paige N., Rumah, Kareem R., Gauthier, Susan A., Fischetti, Vincent A., McClane, Bruce A., Uzal, Francisco A., Zexter, Lily, Mazzucco, Michael, Rudick, Richard, Danko, David, Balmuth, Evan, Nealon, Nancy, Perumal, Jai, Kaunzner, Ulrike, Brito, Ilana L., Chen, Zhengming, Xiang, Jenny Z., Betel, Doron, Daneman, Richard, Sonnenberg, Gregory F., Mason, Christopher E., Vartanian, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145940/
https://www.ncbi.nlm.nih.gov/pubmed/36853799
http://dx.doi.org/10.1172/JCI163239

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