Intrinsic RIG-I restrains STAT5 activation to modulate antitumor activity of CD8(+) T cells

Antitumor activity of CD8(+) T cells is potentially restrained by a variety of negative regulatory pathways that are triggered in the tumor microenvironment, yet, the exact mechanisms remain incompletely defined. Here, we report that intrinsic RIG-I in CD8(+) T cells represents such a factor, as evi...

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Detalles Bibliográficos
Autores principales: Jiang, Xinyi, Lin, Jian, Shangguan, Chengfang, Wang, Xiaoyao, Xiang, Bin, Chen, Juan, Guo, Hezhou, Zhang, Wu, Zhang, Jun, Shi, Yan, Zhu, Jiang, Yang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145944/
https://www.ncbi.nlm.nih.gov/pubmed/36927693
http://dx.doi.org/10.1172/JCI160790

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