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Intrinsic RIG-I restrains STAT5 activation to modulate antitumor activity of CD8(+) T cells
Antitumor activity of CD8(+) T cells is potentially restrained by a variety of negative regulatory pathways that are triggered in the tumor microenvironment, yet, the exact mechanisms remain incompletely defined. Here, we report that intrinsic RIG-I in CD8(+) T cells represents such a factor, as evi...
Asıl Yazarlar: | , , , , , , , , , , , |
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Materyal Türü: | Online Makale Metin |
Dil: | English |
Baskı/Yayın Bilgisi: |
American Society for Clinical Investigation
2023
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Konular: | |
Online Erişim: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145944/ https://www.ncbi.nlm.nih.gov/pubmed/36927693 http://dx.doi.org/10.1172/JCI160790 |