Overexpression of Global Regulator SCrp Leads to the Discovery of New Angucyclines in Streptomyces sp. XS-16

Six angucyclines including three unreported compounds (1–3) were isolated from Streptomyces sp. XS-16 by overexpressing the native global regulator of SCrp (cyclic AMP receptor). The structures were characterized based on nuclear magnetic resonance (NMR) and spectrometry analysis and assisted by ele...

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Detalles Bibliográficos
Autores principales: Xu, Xiao, Zhang, Falei, Zhou, Luning, Chang, Yimin, Che, Qian, Zhu, Tianjiao, Li, Dehai, Zhang, Guojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146017/
https://www.ncbi.nlm.nih.gov/pubmed/37103379
http://dx.doi.org/10.3390/md21040240
Descripción
Sumario:Six angucyclines including three unreported compounds (1–3) were isolated from Streptomyces sp. XS-16 by overexpressing the native global regulator of SCrp (cyclic AMP receptor). The structures were characterized based on nuclear magnetic resonance (NMR) and spectrometry analysis and assisted by electronic circular dichroism (ECD) calculations. All compounds were tested for their antitumor and antimicrobial activities, and compound 1 showed different inhibitory activities against various tumor cell lines with IC(50) values ranging from 0.32 to 5.33 μM.

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