Overexpression of Global Regulator SCrp Leads to the Discovery of New Angucyclines in Streptomyces sp. XS-16

Six angucyclines including three unreported compounds (1–3) were isolated from Streptomyces sp. XS-16 by overexpressing the native global regulator of SCrp (cyclic AMP receptor). The structures were characterized based on nuclear magnetic resonance (NMR) and spectrometry analysis and assisted by ele...

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Detalles Bibliográficos
Autores principales: Xu, Xiao, Zhang, Falei, Zhou, Luning, Chang, Yimin, Che, Qian, Zhu, Tianjiao, Li, Dehai, Zhang, Guojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146017/
https://www.ncbi.nlm.nih.gov/pubmed/37103379
http://dx.doi.org/10.3390/md21040240
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author Xu, Xiao
Zhang, Falei
Zhou, Luning
Chang, Yimin
Che, Qian
Zhu, Tianjiao
Li, Dehai
Zhang, Guojian
author_facet Xu, Xiao
Zhang, Falei
Zhou, Luning
Chang, Yimin
Che, Qian
Zhu, Tianjiao
Li, Dehai
Zhang, Guojian
author_sort Xu, Xiao
collection PubMed
description Six angucyclines including three unreported compounds (1–3) were isolated from Streptomyces sp. XS-16 by overexpressing the native global regulator of SCrp (cyclic AMP receptor). The structures were characterized based on nuclear magnetic resonance (NMR) and spectrometry analysis and assisted by electronic circular dichroism (ECD) calculations. All compounds were tested for their antitumor and antimicrobial activities, and compound 1 showed different inhibitory activities against various tumor cell lines with IC(50) values ranging from 0.32 to 5.33 μM.
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spelling pubmed-101460172023-04-29 Overexpression of Global Regulator SCrp Leads to the Discovery of New Angucyclines in Streptomyces sp. XS-16 Xu, Xiao Zhang, Falei Zhou, Luning Chang, Yimin Che, Qian Zhu, Tianjiao Li, Dehai Zhang, Guojian Mar Drugs Article Six angucyclines including three unreported compounds (1–3) were isolated from Streptomyces sp. XS-16 by overexpressing the native global regulator of SCrp (cyclic AMP receptor). The structures were characterized based on nuclear magnetic resonance (NMR) and spectrometry analysis and assisted by electronic circular dichroism (ECD) calculations. All compounds were tested for their antitumor and antimicrobial activities, and compound 1 showed different inhibitory activities against various tumor cell lines with IC(50) values ranging from 0.32 to 5.33 μM. MDPI 2023-04-14 /pmc/articles/PMC10146017/ /pubmed/37103379 http://dx.doi.org/10.3390/md21040240 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xu, Xiao
Zhang, Falei
Zhou, Luning
Chang, Yimin
Che, Qian
Zhu, Tianjiao
Li, Dehai
Zhang, Guojian
Overexpression of Global Regulator SCrp Leads to the Discovery of New Angucyclines in Streptomyces sp. XS-16
title Overexpression of Global Regulator SCrp Leads to the Discovery of New Angucyclines in Streptomyces sp. XS-16
title_full Overexpression of Global Regulator SCrp Leads to the Discovery of New Angucyclines in Streptomyces sp. XS-16
title_fullStr Overexpression of Global Regulator SCrp Leads to the Discovery of New Angucyclines in Streptomyces sp. XS-16
title_full_unstemmed Overexpression of Global Regulator SCrp Leads to the Discovery of New Angucyclines in Streptomyces sp. XS-16
title_short Overexpression of Global Regulator SCrp Leads to the Discovery of New Angucyclines in Streptomyces sp. XS-16
title_sort overexpression of global regulator scrp leads to the discovery of new angucyclines in streptomyces sp. xs-16
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146017/
https://www.ncbi.nlm.nih.gov/pubmed/37103379
http://dx.doi.org/10.3390/md21040240
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