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Human Papilloma Virus: An Unraveled Enigma of Universal Burden of Malignancies

HPV, or Human Papilloma Virus, has been the primary causative agent of genital warts and cervical cancer worldwide. It is a sexually transmitted infection mainly affecting women of reproductive age group, also infecting men and high-risk group individuals globally, resulting in high mortality. In re...

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Autores principales: Khan, Ishrat, Harshithkumar, R, More, Ashwini, Mukherjee, Anupam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146077/
https://www.ncbi.nlm.nih.gov/pubmed/37111450
http://dx.doi.org/10.3390/pathogens12040564
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author Khan, Ishrat
Harshithkumar, R
More, Ashwini
Mukherjee, Anupam
author_facet Khan, Ishrat
Harshithkumar, R
More, Ashwini
Mukherjee, Anupam
author_sort Khan, Ishrat
collection PubMed
description HPV, or Human Papilloma Virus, has been the primary causative agent of genital warts and cervical cancer worldwide. It is a sexually transmitted infection mainly affecting women of reproductive age group, also infecting men and high-risk group individuals globally, resulting in high mortality. In recent years, HPV has also been found to be the major culprit behind anogenital cancers in both gender and oropharyngeal and colorectal cancers. Few studies have reported the incidence of HPV in breast cancers as well. For a few decades, the burden of HPV-associated malignancies has been increasing at an alarming rate due to a lack of adequate awareness, famine vaccine coverage and hesitancy. The effectiveness of currently available vaccines has been limited to prophylactic efficacy and does not prevent malignancies associated with post-exposure persistent infection. This review focuses on the current burden of HPV-associated malignancies, their causes and strategies to combat the growing prevalence of the cancers. With the advent of new technologies associated with treatment pertaining to therapeutic interventions and employing effective vaccine coverage, the burden of this disease may be reduced in the population.
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spelling pubmed-101460772023-04-29 Human Papilloma Virus: An Unraveled Enigma of Universal Burden of Malignancies Khan, Ishrat Harshithkumar, R More, Ashwini Mukherjee, Anupam Pathogens Review HPV, or Human Papilloma Virus, has been the primary causative agent of genital warts and cervical cancer worldwide. It is a sexually transmitted infection mainly affecting women of reproductive age group, also infecting men and high-risk group individuals globally, resulting in high mortality. In recent years, HPV has also been found to be the major culprit behind anogenital cancers in both gender and oropharyngeal and colorectal cancers. Few studies have reported the incidence of HPV in breast cancers as well. For a few decades, the burden of HPV-associated malignancies has been increasing at an alarming rate due to a lack of adequate awareness, famine vaccine coverage and hesitancy. The effectiveness of currently available vaccines has been limited to prophylactic efficacy and does not prevent malignancies associated with post-exposure persistent infection. This review focuses on the current burden of HPV-associated malignancies, their causes and strategies to combat the growing prevalence of the cancers. With the advent of new technologies associated with treatment pertaining to therapeutic interventions and employing effective vaccine coverage, the burden of this disease may be reduced in the population. MDPI 2023-04-06 /pmc/articles/PMC10146077/ /pubmed/37111450 http://dx.doi.org/10.3390/pathogens12040564 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khan, Ishrat
Harshithkumar, R
More, Ashwini
Mukherjee, Anupam
Human Papilloma Virus: An Unraveled Enigma of Universal Burden of Malignancies
title Human Papilloma Virus: An Unraveled Enigma of Universal Burden of Malignancies
title_full Human Papilloma Virus: An Unraveled Enigma of Universal Burden of Malignancies
title_fullStr Human Papilloma Virus: An Unraveled Enigma of Universal Burden of Malignancies
title_full_unstemmed Human Papilloma Virus: An Unraveled Enigma of Universal Burden of Malignancies
title_short Human Papilloma Virus: An Unraveled Enigma of Universal Burden of Malignancies
title_sort human papilloma virus: an unraveled enigma of universal burden of malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146077/
https://www.ncbi.nlm.nih.gov/pubmed/37111450
http://dx.doi.org/10.3390/pathogens12040564
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