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Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular Cancers
Phosphodiesterases are key regulators that fine tune the intracellular levels of cyclic nucleotides, given their ability to hydrolyze cAMP and cGMP. They are critical regulators of cAMP/cGMP-mediated signaling pathways, modulating their downstream biological effects such as gene expression, cell pro...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146088/ https://www.ncbi.nlm.nih.gov/pubmed/37108780 http://dx.doi.org/10.3390/ijms24087617 |
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author | Campolo, Federica Assenza, Maria Rita Venneri, Mary Anna Barbagallo, Federica |
author_facet | Campolo, Federica Assenza, Maria Rita Venneri, Mary Anna Barbagallo, Federica |
author_sort | Campolo, Federica |
collection | PubMed |
description | Phosphodiesterases are key regulators that fine tune the intracellular levels of cyclic nucleotides, given their ability to hydrolyze cAMP and cGMP. They are critical regulators of cAMP/cGMP-mediated signaling pathways, modulating their downstream biological effects such as gene expression, cell proliferation, cell-cycle regulation but also inflammation and metabolic function. Recently, mutations in PDE genes have been identified and linked to human genetic diseases and PDEs have been demonstrated to play a potential role in predisposition to several tumors, especially in cAMP-sensitive tissues. This review summarizes the current knowledge and most relevant findings regarding the expression and regulation of PDE families in the testis focusing on PDEs role in testicular cancer development. |
format | Online Article Text |
id | pubmed-10146088 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101460882023-04-29 Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular Cancers Campolo, Federica Assenza, Maria Rita Venneri, Mary Anna Barbagallo, Federica Int J Mol Sci Review Phosphodiesterases are key regulators that fine tune the intracellular levels of cyclic nucleotides, given their ability to hydrolyze cAMP and cGMP. They are critical regulators of cAMP/cGMP-mediated signaling pathways, modulating their downstream biological effects such as gene expression, cell proliferation, cell-cycle regulation but also inflammation and metabolic function. Recently, mutations in PDE genes have been identified and linked to human genetic diseases and PDEs have been demonstrated to play a potential role in predisposition to several tumors, especially in cAMP-sensitive tissues. This review summarizes the current knowledge and most relevant findings regarding the expression and regulation of PDE families in the testis focusing on PDEs role in testicular cancer development. MDPI 2023-04-20 /pmc/articles/PMC10146088/ /pubmed/37108780 http://dx.doi.org/10.3390/ijms24087617 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Campolo, Federica Assenza, Maria Rita Venneri, Mary Anna Barbagallo, Federica Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular Cancers |
title | Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular Cancers |
title_full | Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular Cancers |
title_fullStr | Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular Cancers |
title_full_unstemmed | Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular Cancers |
title_short | Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular Cancers |
title_sort | once upon a testis: the tale of cyclic nucleotide phosphodiesterase in testicular cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146088/ https://www.ncbi.nlm.nih.gov/pubmed/37108780 http://dx.doi.org/10.3390/ijms24087617 |
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