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Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways Diseases

Background: Nasal cytology at birth and in the pediatric age is barely investigated regarding its association with the onset of common pediatric diseases. Methods: We enrolled 241 newborns within their first 24 h of life, studying their nasal cellular composition and repeating this at 1 and 3 years...

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Autores principales: Rosso, Cecilia, Turati, Federica, Saibene, Alberto Maria, Verduci, Elvira, Fuccillo, Emanuela, Tavilla, Maria Chiara, Magnani, Mauro, Banderali, Giuseppe, Ferraroni, Monica, De Corso, Eugenio, Felisati, Giovanni, Pipolo, Carlotta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146100/
https://www.ncbi.nlm.nih.gov/pubmed/37109073
http://dx.doi.org/10.3390/jpm13040687
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author Rosso, Cecilia
Turati, Federica
Saibene, Alberto Maria
Verduci, Elvira
Fuccillo, Emanuela
Tavilla, Maria Chiara
Magnani, Mauro
Banderali, Giuseppe
Ferraroni, Monica
De Corso, Eugenio
Felisati, Giovanni
Pipolo, Carlotta
author_facet Rosso, Cecilia
Turati, Federica
Saibene, Alberto Maria
Verduci, Elvira
Fuccillo, Emanuela
Tavilla, Maria Chiara
Magnani, Mauro
Banderali, Giuseppe
Ferraroni, Monica
De Corso, Eugenio
Felisati, Giovanni
Pipolo, Carlotta
author_sort Rosso, Cecilia
collection PubMed
description Background: Nasal cytology at birth and in the pediatric age is barely investigated regarding its association with the onset of common pediatric diseases. Methods: We enrolled 241 newborns within their first 24 h of life, studying their nasal cellular composition and repeating this at 1 and 3 years of life. We collected anamneses of perinatal factors and external factors (parental smoking, passive smoking, breastfeeding), and the prevalence of otitis, rhinosinusitis, bronchitis, asthma, and allergy at all timepoints. Results: 204 children completed the study. At birth, there was a prevalence of ciliated cells and rare neutrophils. At 1 and 3 years, ciliated cells started reducing in favor of muciparous cells and neutrophils. We found that caesarian delivery and nasogastric tube usage for choanal patency are significantly related to a certain cellular nasal composition. Additionally, development of upper respiratory tract infections, AOM (acute otitis media) and allergy correlates with specific cytological compositions which may predict those pathologies. Conclusions: Our study is the first to show the normal nasal mucosa cellular composition and development in the first 3 years of life in a large cohort. Nasal cytology may be a tool for early risk assessment in the occurrence of upper airway disease.
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spelling pubmed-101461002023-04-29 Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways Diseases Rosso, Cecilia Turati, Federica Saibene, Alberto Maria Verduci, Elvira Fuccillo, Emanuela Tavilla, Maria Chiara Magnani, Mauro Banderali, Giuseppe Ferraroni, Monica De Corso, Eugenio Felisati, Giovanni Pipolo, Carlotta J Pers Med Article Background: Nasal cytology at birth and in the pediatric age is barely investigated regarding its association with the onset of common pediatric diseases. Methods: We enrolled 241 newborns within their first 24 h of life, studying their nasal cellular composition and repeating this at 1 and 3 years of life. We collected anamneses of perinatal factors and external factors (parental smoking, passive smoking, breastfeeding), and the prevalence of otitis, rhinosinusitis, bronchitis, asthma, and allergy at all timepoints. Results: 204 children completed the study. At birth, there was a prevalence of ciliated cells and rare neutrophils. At 1 and 3 years, ciliated cells started reducing in favor of muciparous cells and neutrophils. We found that caesarian delivery and nasogastric tube usage for choanal patency are significantly related to a certain cellular nasal composition. Additionally, development of upper respiratory tract infections, AOM (acute otitis media) and allergy correlates with specific cytological compositions which may predict those pathologies. Conclusions: Our study is the first to show the normal nasal mucosa cellular composition and development in the first 3 years of life in a large cohort. Nasal cytology may be a tool for early risk assessment in the occurrence of upper airway disease. MDPI 2023-04-19 /pmc/articles/PMC10146100/ /pubmed/37109073 http://dx.doi.org/10.3390/jpm13040687 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rosso, Cecilia
Turati, Federica
Saibene, Alberto Maria
Verduci, Elvira
Fuccillo, Emanuela
Tavilla, Maria Chiara
Magnani, Mauro
Banderali, Giuseppe
Ferraroni, Monica
De Corso, Eugenio
Felisati, Giovanni
Pipolo, Carlotta
Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways Diseases
title Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways Diseases
title_full Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways Diseases
title_fullStr Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways Diseases
title_full_unstemmed Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways Diseases
title_short Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways Diseases
title_sort nasal cytology on 241 children: from birth to the first 3 years of life and association with common airways diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146100/
https://www.ncbi.nlm.nih.gov/pubmed/37109073
http://dx.doi.org/10.3390/jpm13040687
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