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A Whey-Based Diet Can Ameliorate the Effects of LPS-Induced Growth Attenuation in Young Rats

Chronic inflammation in childhood is associated with impaired growth. In the current study, a lipopolysaccharide (LPS) model of inflammation in young rats was used to study the efficacy of whey-based as compared to soy-based diets to ameliorate growth attenuation. Young rats were injected with LPS a...

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Autores principales: Menahem, Chen, Foist, Michal, Mansour, Yasmin, Shtaif, Biana, Bar-Maisels, Meytal, Phillip, Moshe, Gat-Yablonski, Galia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146220/
https://www.ncbi.nlm.nih.gov/pubmed/37111042
http://dx.doi.org/10.3390/nu15081823
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author Menahem, Chen
Foist, Michal
Mansour, Yasmin
Shtaif, Biana
Bar-Maisels, Meytal
Phillip, Moshe
Gat-Yablonski, Galia
author_facet Menahem, Chen
Foist, Michal
Mansour, Yasmin
Shtaif, Biana
Bar-Maisels, Meytal
Phillip, Moshe
Gat-Yablonski, Galia
author_sort Menahem, Chen
collection PubMed
description Chronic inflammation in childhood is associated with impaired growth. In the current study, a lipopolysaccharide (LPS) model of inflammation in young rats was used to study the efficacy of whey-based as compared to soy-based diets to ameliorate growth attenuation. Young rats were injected with LPS and fed normal chow or diets containing whey or soy as the sole protein source during treatment, or during the recovery period in a separate set of experiments. The body and spleen weight, food consumption, humerus length, and EGP height and structure were evaluated. Inflammatory markers in the spleen and markers of differentiation in the EGP were assessed using qPCR. The LPS led to a significant increase in the spleen weight and a decrease in the EGP height. Whey, but not soy, protected the animals from both effects. In the recovery model, whey led to increased EGP height at both 3 and 16 d post treatment. The most affected region in the EGP was the hypertrophic zone (HZ), which was significantly shortened by the LPS treatment but enlarged by whey. In conclusion, LPS affected the spleen weight and EGP height and had a specific effect on the HZ. Nutrition with whey protein appeared to protect the rats from the LPS-induced growth attenuation.
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spelling pubmed-101462202023-04-29 A Whey-Based Diet Can Ameliorate the Effects of LPS-Induced Growth Attenuation in Young Rats Menahem, Chen Foist, Michal Mansour, Yasmin Shtaif, Biana Bar-Maisels, Meytal Phillip, Moshe Gat-Yablonski, Galia Nutrients Article Chronic inflammation in childhood is associated with impaired growth. In the current study, a lipopolysaccharide (LPS) model of inflammation in young rats was used to study the efficacy of whey-based as compared to soy-based diets to ameliorate growth attenuation. Young rats were injected with LPS and fed normal chow or diets containing whey or soy as the sole protein source during treatment, or during the recovery period in a separate set of experiments. The body and spleen weight, food consumption, humerus length, and EGP height and structure were evaluated. Inflammatory markers in the spleen and markers of differentiation in the EGP were assessed using qPCR. The LPS led to a significant increase in the spleen weight and a decrease in the EGP height. Whey, but not soy, protected the animals from both effects. In the recovery model, whey led to increased EGP height at both 3 and 16 d post treatment. The most affected region in the EGP was the hypertrophic zone (HZ), which was significantly shortened by the LPS treatment but enlarged by whey. In conclusion, LPS affected the spleen weight and EGP height and had a specific effect on the HZ. Nutrition with whey protein appeared to protect the rats from the LPS-induced growth attenuation. MDPI 2023-04-10 /pmc/articles/PMC10146220/ /pubmed/37111042 http://dx.doi.org/10.3390/nu15081823 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Menahem, Chen
Foist, Michal
Mansour, Yasmin
Shtaif, Biana
Bar-Maisels, Meytal
Phillip, Moshe
Gat-Yablonski, Galia
A Whey-Based Diet Can Ameliorate the Effects of LPS-Induced Growth Attenuation in Young Rats
title A Whey-Based Diet Can Ameliorate the Effects of LPS-Induced Growth Attenuation in Young Rats
title_full A Whey-Based Diet Can Ameliorate the Effects of LPS-Induced Growth Attenuation in Young Rats
title_fullStr A Whey-Based Diet Can Ameliorate the Effects of LPS-Induced Growth Attenuation in Young Rats
title_full_unstemmed A Whey-Based Diet Can Ameliorate the Effects of LPS-Induced Growth Attenuation in Young Rats
title_short A Whey-Based Diet Can Ameliorate the Effects of LPS-Induced Growth Attenuation in Young Rats
title_sort whey-based diet can ameliorate the effects of lps-induced growth attenuation in young rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146220/
https://www.ncbi.nlm.nih.gov/pubmed/37111042
http://dx.doi.org/10.3390/nu15081823
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