Cargando…

Altered Glycosylation in Progression and Management of Bladder Cancer

Bladder cancer (BC) is the 10th most common malignancy worldwide, with an estimated 573,000 new cases and 213,000 deaths in 2020. Available therapeutic approaches are still unable to reduce the incidence of BC metastasis and the high mortality rates of BC patients. Therefore, there is a need to deep...

Descripción completa

Detalles Bibliográficos
Autores principales: Wilczak, Magdalena, Surman, Magdalena, Przybyło, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146225/
https://www.ncbi.nlm.nih.gov/pubmed/37110670
http://dx.doi.org/10.3390/molecules28083436
_version_ 1785034530015412224
author Wilczak, Magdalena
Surman, Magdalena
Przybyło, Małgorzata
author_facet Wilczak, Magdalena
Surman, Magdalena
Przybyło, Małgorzata
author_sort Wilczak, Magdalena
collection PubMed
description Bladder cancer (BC) is the 10th most common malignancy worldwide, with an estimated 573,000 new cases and 213,000 deaths in 2020. Available therapeutic approaches are still unable to reduce the incidence of BC metastasis and the high mortality rates of BC patients. Therefore, there is a need to deepen our understanding of the molecular mechanisms underlying BC progression to develop new diagnostic and therapeutic tools. One such mechanism is protein glycosylation. Numerous studies reported changes in glycan biosynthesis during neoplastic transformation, resulting in the appearance of the so-called tumor-associated carbohydrate antigens (TACAs) on the cell surface. TACAs affect a wide range of key biological processes, including tumor cell survival and proliferation, invasion and metastasis, induction of chronic inflammation, angiogenesis, immune evasion, and insensitivity to apoptosis. The purpose of this review is to summarize the current information on how altered glycosylation of bladder cancer cells promotes disease progression and to present the potential use of glycans for diagnostic and therapeutic purposes.
format Online
Article
Text
id pubmed-10146225
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101462252023-04-29 Altered Glycosylation in Progression and Management of Bladder Cancer Wilczak, Magdalena Surman, Magdalena Przybyło, Małgorzata Molecules Review Bladder cancer (BC) is the 10th most common malignancy worldwide, with an estimated 573,000 new cases and 213,000 deaths in 2020. Available therapeutic approaches are still unable to reduce the incidence of BC metastasis and the high mortality rates of BC patients. Therefore, there is a need to deepen our understanding of the molecular mechanisms underlying BC progression to develop new diagnostic and therapeutic tools. One such mechanism is protein glycosylation. Numerous studies reported changes in glycan biosynthesis during neoplastic transformation, resulting in the appearance of the so-called tumor-associated carbohydrate antigens (TACAs) on the cell surface. TACAs affect a wide range of key biological processes, including tumor cell survival and proliferation, invasion and metastasis, induction of chronic inflammation, angiogenesis, immune evasion, and insensitivity to apoptosis. The purpose of this review is to summarize the current information on how altered glycosylation of bladder cancer cells promotes disease progression and to present the potential use of glycans for diagnostic and therapeutic purposes. MDPI 2023-04-13 /pmc/articles/PMC10146225/ /pubmed/37110670 http://dx.doi.org/10.3390/molecules28083436 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wilczak, Magdalena
Surman, Magdalena
Przybyło, Małgorzata
Altered Glycosylation in Progression and Management of Bladder Cancer
title Altered Glycosylation in Progression and Management of Bladder Cancer
title_full Altered Glycosylation in Progression and Management of Bladder Cancer
title_fullStr Altered Glycosylation in Progression and Management of Bladder Cancer
title_full_unstemmed Altered Glycosylation in Progression and Management of Bladder Cancer
title_short Altered Glycosylation in Progression and Management of Bladder Cancer
title_sort altered glycosylation in progression and management of bladder cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146225/
https://www.ncbi.nlm.nih.gov/pubmed/37110670
http://dx.doi.org/10.3390/molecules28083436
work_keys_str_mv AT wilczakmagdalena alteredglycosylationinprogressionandmanagementofbladdercancer
AT surmanmagdalena alteredglycosylationinprogressionandmanagementofbladdercancer
AT przybyłomałgorzata alteredglycosylationinprogressionandmanagementofbladdercancer