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Altered Glycosylation in Progression and Management of Bladder Cancer
Bladder cancer (BC) is the 10th most common malignancy worldwide, with an estimated 573,000 new cases and 213,000 deaths in 2020. Available therapeutic approaches are still unable to reduce the incidence of BC metastasis and the high mortality rates of BC patients. Therefore, there is a need to deep...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146225/ https://www.ncbi.nlm.nih.gov/pubmed/37110670 http://dx.doi.org/10.3390/molecules28083436 |
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author | Wilczak, Magdalena Surman, Magdalena Przybyło, Małgorzata |
author_facet | Wilczak, Magdalena Surman, Magdalena Przybyło, Małgorzata |
author_sort | Wilczak, Magdalena |
collection | PubMed |
description | Bladder cancer (BC) is the 10th most common malignancy worldwide, with an estimated 573,000 new cases and 213,000 deaths in 2020. Available therapeutic approaches are still unable to reduce the incidence of BC metastasis and the high mortality rates of BC patients. Therefore, there is a need to deepen our understanding of the molecular mechanisms underlying BC progression to develop new diagnostic and therapeutic tools. One such mechanism is protein glycosylation. Numerous studies reported changes in glycan biosynthesis during neoplastic transformation, resulting in the appearance of the so-called tumor-associated carbohydrate antigens (TACAs) on the cell surface. TACAs affect a wide range of key biological processes, including tumor cell survival and proliferation, invasion and metastasis, induction of chronic inflammation, angiogenesis, immune evasion, and insensitivity to apoptosis. The purpose of this review is to summarize the current information on how altered glycosylation of bladder cancer cells promotes disease progression and to present the potential use of glycans for diagnostic and therapeutic purposes. |
format | Online Article Text |
id | pubmed-10146225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101462252023-04-29 Altered Glycosylation in Progression and Management of Bladder Cancer Wilczak, Magdalena Surman, Magdalena Przybyło, Małgorzata Molecules Review Bladder cancer (BC) is the 10th most common malignancy worldwide, with an estimated 573,000 new cases and 213,000 deaths in 2020. Available therapeutic approaches are still unable to reduce the incidence of BC metastasis and the high mortality rates of BC patients. Therefore, there is a need to deepen our understanding of the molecular mechanisms underlying BC progression to develop new diagnostic and therapeutic tools. One such mechanism is protein glycosylation. Numerous studies reported changes in glycan biosynthesis during neoplastic transformation, resulting in the appearance of the so-called tumor-associated carbohydrate antigens (TACAs) on the cell surface. TACAs affect a wide range of key biological processes, including tumor cell survival and proliferation, invasion and metastasis, induction of chronic inflammation, angiogenesis, immune evasion, and insensitivity to apoptosis. The purpose of this review is to summarize the current information on how altered glycosylation of bladder cancer cells promotes disease progression and to present the potential use of glycans for diagnostic and therapeutic purposes. MDPI 2023-04-13 /pmc/articles/PMC10146225/ /pubmed/37110670 http://dx.doi.org/10.3390/molecules28083436 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wilczak, Magdalena Surman, Magdalena Przybyło, Małgorzata Altered Glycosylation in Progression and Management of Bladder Cancer |
title | Altered Glycosylation in Progression and Management of Bladder Cancer |
title_full | Altered Glycosylation in Progression and Management of Bladder Cancer |
title_fullStr | Altered Glycosylation in Progression and Management of Bladder Cancer |
title_full_unstemmed | Altered Glycosylation in Progression and Management of Bladder Cancer |
title_short | Altered Glycosylation in Progression and Management of Bladder Cancer |
title_sort | altered glycosylation in progression and management of bladder cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146225/ https://www.ncbi.nlm.nih.gov/pubmed/37110670 http://dx.doi.org/10.3390/molecules28083436 |
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