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Metabolic Inheritance and the Competition for Calories between Mother and Fetus

During the prenatal period, maternal and fetal cells compete for calories and nutrients. To ensure the survival of the mother and development of the fetus, the prenatal hormonal milieu alters the competitive environment via metabolic perturbations (e.g., insulin resistance). These perturbations incr...

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Autores principales: Archer, Edward, Lavie, Carl J., Dobersek, Urska, Hill, James O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146335/
https://www.ncbi.nlm.nih.gov/pubmed/37110203
http://dx.doi.org/10.3390/metabo13040545
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author Archer, Edward
Lavie, Carl J.
Dobersek, Urska
Hill, James O.
author_facet Archer, Edward
Lavie, Carl J.
Dobersek, Urska
Hill, James O.
author_sort Archer, Edward
collection PubMed
description During the prenatal period, maternal and fetal cells compete for calories and nutrients. To ensure the survival of the mother and development of the fetus, the prenatal hormonal milieu alters the competitive environment via metabolic perturbations (e.g., insulin resistance). These perturbations increase maternal caloric consumption and engender increments in both maternal fat mass and the number of calories captured by the fetus. However, a mother’s metabolic and behavioral phenotypes (e.g., physical activity levels) and her external environment (e.g., food availability) can asymmetrically impact the competitive milieu, leading to irreversible changes in pre- and post-natal development—as exhibited by stunting and obesity. Therefore, the interaction of maternal metabolism, behavior, and environment impact the competition for calories—which in turn creates a continuum of health trajectories in offspring. In sum, the inheritance of metabolic phenotypes offers a comprehensive and consilient explanation for much of the increase in obesity and T2DM over the past 50 years in human and non-human mammals.
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spelling pubmed-101463352023-04-29 Metabolic Inheritance and the Competition for Calories between Mother and Fetus Archer, Edward Lavie, Carl J. Dobersek, Urska Hill, James O. Metabolites Hypothesis During the prenatal period, maternal and fetal cells compete for calories and nutrients. To ensure the survival of the mother and development of the fetus, the prenatal hormonal milieu alters the competitive environment via metabolic perturbations (e.g., insulin resistance). These perturbations increase maternal caloric consumption and engender increments in both maternal fat mass and the number of calories captured by the fetus. However, a mother’s metabolic and behavioral phenotypes (e.g., physical activity levels) and her external environment (e.g., food availability) can asymmetrically impact the competitive milieu, leading to irreversible changes in pre- and post-natal development—as exhibited by stunting and obesity. Therefore, the interaction of maternal metabolism, behavior, and environment impact the competition for calories—which in turn creates a continuum of health trajectories in offspring. In sum, the inheritance of metabolic phenotypes offers a comprehensive and consilient explanation for much of the increase in obesity and T2DM over the past 50 years in human and non-human mammals. MDPI 2023-04-11 /pmc/articles/PMC10146335/ /pubmed/37110203 http://dx.doi.org/10.3390/metabo13040545 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Hypothesis
Archer, Edward
Lavie, Carl J.
Dobersek, Urska
Hill, James O.
Metabolic Inheritance and the Competition for Calories between Mother and Fetus
title Metabolic Inheritance and the Competition for Calories between Mother and Fetus
title_full Metabolic Inheritance and the Competition for Calories between Mother and Fetus
title_fullStr Metabolic Inheritance and the Competition for Calories between Mother and Fetus
title_full_unstemmed Metabolic Inheritance and the Competition for Calories between Mother and Fetus
title_short Metabolic Inheritance and the Competition for Calories between Mother and Fetus
title_sort metabolic inheritance and the competition for calories between mother and fetus
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146335/
https://www.ncbi.nlm.nih.gov/pubmed/37110203
http://dx.doi.org/10.3390/metabo13040545
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