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Baicalin—Current Trends in Detection Methods and Health-Promoting Properties

Baicalin (7-D-glucuronic acid-5,6-dihydroxyflavone) belongs to natural flavonoids extracted from the roots of Scutellaria baicalensis, the plant used in traditional Chinese medicine. It has been proven that baicalin has various pharmacological activities, such as antioxidant, anti-inflammatory, anti...

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Autores principales: Bajek-Bil, Agata, Chmiel, Marcelina, Włoch, Aleksandra, Stompor-Gorący, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146343/
https://www.ncbi.nlm.nih.gov/pubmed/37111327
http://dx.doi.org/10.3390/ph16040570
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author Bajek-Bil, Agata
Chmiel, Marcelina
Włoch, Aleksandra
Stompor-Gorący, Monika
author_facet Bajek-Bil, Agata
Chmiel, Marcelina
Włoch, Aleksandra
Stompor-Gorący, Monika
author_sort Bajek-Bil, Agata
collection PubMed
description Baicalin (7-D-glucuronic acid-5,6-dihydroxyflavone) belongs to natural flavonoids extracted from the roots of Scutellaria baicalensis, the plant used in traditional Chinese medicine. It has been proven that baicalin has various pharmacological activities, such as antioxidant, anti-inflammatory, anticancer, antibacterial, and anti-apoptotic ones. However, it is essential not only to determine the medical usefulness of baicalin, but also to find and develop the most effective methods for its extraction and detection. Therefore, the aim of this review was to summarize the current methods of detection and identification of baicalin and to present the medical applications of baicalin and the underlying mechanisms of its action. Based on the review of the latest literature, it can be concluded that liquid chromatography alone or together with mass spectrometry is the most commonly used method for the determination of baicalin. Recently, also new electrochemical methods have been established, e.g., biosensors with fluorescence, which have better detection limits, sensitivity, and selectivity.
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spelling pubmed-101463432023-04-29 Baicalin—Current Trends in Detection Methods and Health-Promoting Properties Bajek-Bil, Agata Chmiel, Marcelina Włoch, Aleksandra Stompor-Gorący, Monika Pharmaceuticals (Basel) Review Baicalin (7-D-glucuronic acid-5,6-dihydroxyflavone) belongs to natural flavonoids extracted from the roots of Scutellaria baicalensis, the plant used in traditional Chinese medicine. It has been proven that baicalin has various pharmacological activities, such as antioxidant, anti-inflammatory, anticancer, antibacterial, and anti-apoptotic ones. However, it is essential not only to determine the medical usefulness of baicalin, but also to find and develop the most effective methods for its extraction and detection. Therefore, the aim of this review was to summarize the current methods of detection and identification of baicalin and to present the medical applications of baicalin and the underlying mechanisms of its action. Based on the review of the latest literature, it can be concluded that liquid chromatography alone or together with mass spectrometry is the most commonly used method for the determination of baicalin. Recently, also new electrochemical methods have been established, e.g., biosensors with fluorescence, which have better detection limits, sensitivity, and selectivity. MDPI 2023-04-10 /pmc/articles/PMC10146343/ /pubmed/37111327 http://dx.doi.org/10.3390/ph16040570 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bajek-Bil, Agata
Chmiel, Marcelina
Włoch, Aleksandra
Stompor-Gorący, Monika
Baicalin—Current Trends in Detection Methods and Health-Promoting Properties
title Baicalin—Current Trends in Detection Methods and Health-Promoting Properties
title_full Baicalin—Current Trends in Detection Methods and Health-Promoting Properties
title_fullStr Baicalin—Current Trends in Detection Methods and Health-Promoting Properties
title_full_unstemmed Baicalin—Current Trends in Detection Methods and Health-Promoting Properties
title_short Baicalin—Current Trends in Detection Methods and Health-Promoting Properties
title_sort baicalin—current trends in detection methods and health-promoting properties
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146343/
https://www.ncbi.nlm.nih.gov/pubmed/37111327
http://dx.doi.org/10.3390/ph16040570
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