Probable Enoxaparin-Induced Liver Injury in a Young Patient: A Case Report of a Diagnostic Challenge

Low molecular weight heparin (LMWH) is associated with elevated liver enzyme levels in a small percentage of patients. Elevations more than five times the upper limit of normal are uncommon and have been noted to primarily occur in patients receiving higher doses. The literature reports mild, primar...

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Autores principales: Eze, Ikechukwu E, Adidam, Sneha, Gordon, Domonick K, Lasisi, Oluwatobi G, Gajjala, Jhansi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146374/
https://www.ncbi.nlm.nih.gov/pubmed/37123692
http://dx.doi.org/10.7759/cureus.36869
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author Eze, Ikechukwu E
Adidam, Sneha
Gordon, Domonick K
Lasisi, Oluwatobi G
Gajjala, Jhansi
author_facet Eze, Ikechukwu E
Adidam, Sneha
Gordon, Domonick K
Lasisi, Oluwatobi G
Gajjala, Jhansi
author_sort Eze, Ikechukwu E
collection PubMed
description Low molecular weight heparin (LMWH) is associated with elevated liver enzyme levels in a small percentage of patients. Elevations more than five times the upper limit of normal are uncommon and have been noted to primarily occur in patients receiving higher doses. The literature reports mild, primarily asymptomatic cases, with adverse effects at higher therapeutic doses. We report the case of a 27-year-old woman who developed drug-induced liver injury (DILI) while receiving enoxaparin during admission for a loculated pleural effusion secondary to pulmonary tuberculosis. The Roussel Uclaf Causality Assessment Method (RUCAM) score delineated enoxaparin as the likely cause.
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spelling pubmed-101463742023-04-29 Probable Enoxaparin-Induced Liver Injury in a Young Patient: A Case Report of a Diagnostic Challenge Eze, Ikechukwu E Adidam, Sneha Gordon, Domonick K Lasisi, Oluwatobi G Gajjala, Jhansi Cureus Internal Medicine Low molecular weight heparin (LMWH) is associated with elevated liver enzyme levels in a small percentage of patients. Elevations more than five times the upper limit of normal are uncommon and have been noted to primarily occur in patients receiving higher doses. The literature reports mild, primarily asymptomatic cases, with adverse effects at higher therapeutic doses. We report the case of a 27-year-old woman who developed drug-induced liver injury (DILI) while receiving enoxaparin during admission for a loculated pleural effusion secondary to pulmonary tuberculosis. The Roussel Uclaf Causality Assessment Method (RUCAM) score delineated enoxaparin as the likely cause. Cureus 2023-03-29 /pmc/articles/PMC10146374/ /pubmed/37123692 http://dx.doi.org/10.7759/cureus.36869 Text en Copyright © 2023, Eze et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Eze, Ikechukwu E
Adidam, Sneha
Gordon, Domonick K
Lasisi, Oluwatobi G
Gajjala, Jhansi
Probable Enoxaparin-Induced Liver Injury in a Young Patient: A Case Report of a Diagnostic Challenge
title Probable Enoxaparin-Induced Liver Injury in a Young Patient: A Case Report of a Diagnostic Challenge
title_full Probable Enoxaparin-Induced Liver Injury in a Young Patient: A Case Report of a Diagnostic Challenge
title_fullStr Probable Enoxaparin-Induced Liver Injury in a Young Patient: A Case Report of a Diagnostic Challenge
title_full_unstemmed Probable Enoxaparin-Induced Liver Injury in a Young Patient: A Case Report of a Diagnostic Challenge
title_short Probable Enoxaparin-Induced Liver Injury in a Young Patient: A Case Report of a Diagnostic Challenge
title_sort probable enoxaparin-induced liver injury in a young patient: a case report of a diagnostic challenge
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146374/
https://www.ncbi.nlm.nih.gov/pubmed/37123692
http://dx.doi.org/10.7759/cureus.36869
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