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Serum Lactate-Albumin Ratio: Soothsayer for Outcome in Sepsis

Aim: The aim of this study is to assess the efficacy of the serum lactate/albumin (L/A) ratio as a prognostic marker of sepsis syndrome. Materials and methods: This study was conducted in the Internal Medicine Department at Acharya Vinoba Bhave Rural Hospital with a sample size of 160 cases of sepsi...

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Autores principales: Kabra, Ruchita, Acharya, Sourya, Shukla, Samarth, Kumar, Sunil, Wanjari, Anil, Mahajan, Satish, Gaidhane, Shilpa A, Bhansali, Pratik J, Wasnik, Praful
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146386/
https://www.ncbi.nlm.nih.gov/pubmed/37123772
http://dx.doi.org/10.7759/cureus.36816
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author Kabra, Ruchita
Acharya, Sourya
Shukla, Samarth
Kumar, Sunil
Wanjari, Anil
Mahajan, Satish
Gaidhane, Shilpa A
Bhansali, Pratik J
Wasnik, Praful
author_facet Kabra, Ruchita
Acharya, Sourya
Shukla, Samarth
Kumar, Sunil
Wanjari, Anil
Mahajan, Satish
Gaidhane, Shilpa A
Bhansali, Pratik J
Wasnik, Praful
author_sort Kabra, Ruchita
collection PubMed
description Aim: The aim of this study is to assess the efficacy of the serum lactate/albumin (L/A) ratio as a prognostic marker of sepsis syndrome. Materials and methods: This study was conducted in the Internal Medicine Department at Acharya Vinoba Bhave Rural Hospital with a sample size of 160 cases of sepsis. The serum L/A ratio was calculated on admission and correlated with deaths and morbidity. Statistical analysis was significant if the P-value was less than 0.05. Results: The mean age of patients was 52.83 ± 16.80 years with a male predominance (64.4% vs. 35.6%). The mean L/A ratio was 0.95 ± 0.46. The proportion of discharged subjects and mortality were 58.8% and 41.2%, respectively. The study found that a higher mean L/A ratio (1.1-1.44) was significantly linked to the various variables in the study. Furthermore, a significantly higher median L/A ratio of 1.23 was found in subjects with vasopressor use. The median L/A ratio in the Discharge group and Death group was 0.64 and 1.27, respectively. The area under the receiver operating characteristic (AUROC) curve indicated that accurate diagnostic performance was 0.976 in predicting Death versus Discharge for the L/A ratio. Conclusion: This study found that, compared to lactate and albumin alone, the predictor value of the L/A ratio was outstanding in predicting death and hospital stay (discharge) among sepsis participants, with a sensitivity of 100% and a specificity of 88%.
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spelling pubmed-101463862023-04-29 Serum Lactate-Albumin Ratio: Soothsayer for Outcome in Sepsis Kabra, Ruchita Acharya, Sourya Shukla, Samarth Kumar, Sunil Wanjari, Anil Mahajan, Satish Gaidhane, Shilpa A Bhansali, Pratik J Wasnik, Praful Cureus Internal Medicine Aim: The aim of this study is to assess the efficacy of the serum lactate/albumin (L/A) ratio as a prognostic marker of sepsis syndrome. Materials and methods: This study was conducted in the Internal Medicine Department at Acharya Vinoba Bhave Rural Hospital with a sample size of 160 cases of sepsis. The serum L/A ratio was calculated on admission and correlated with deaths and morbidity. Statistical analysis was significant if the P-value was less than 0.05. Results: The mean age of patients was 52.83 ± 16.80 years with a male predominance (64.4% vs. 35.6%). The mean L/A ratio was 0.95 ± 0.46. The proportion of discharged subjects and mortality were 58.8% and 41.2%, respectively. The study found that a higher mean L/A ratio (1.1-1.44) was significantly linked to the various variables in the study. Furthermore, a significantly higher median L/A ratio of 1.23 was found in subjects with vasopressor use. The median L/A ratio in the Discharge group and Death group was 0.64 and 1.27, respectively. The area under the receiver operating characteristic (AUROC) curve indicated that accurate diagnostic performance was 0.976 in predicting Death versus Discharge for the L/A ratio. Conclusion: This study found that, compared to lactate and albumin alone, the predictor value of the L/A ratio was outstanding in predicting death and hospital stay (discharge) among sepsis participants, with a sensitivity of 100% and a specificity of 88%. Cureus 2023-03-28 /pmc/articles/PMC10146386/ /pubmed/37123772 http://dx.doi.org/10.7759/cureus.36816 Text en Copyright © 2023, Kabra et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Kabra, Ruchita
Acharya, Sourya
Shukla, Samarth
Kumar, Sunil
Wanjari, Anil
Mahajan, Satish
Gaidhane, Shilpa A
Bhansali, Pratik J
Wasnik, Praful
Serum Lactate-Albumin Ratio: Soothsayer for Outcome in Sepsis
title Serum Lactate-Albumin Ratio: Soothsayer for Outcome in Sepsis
title_full Serum Lactate-Albumin Ratio: Soothsayer for Outcome in Sepsis
title_fullStr Serum Lactate-Albumin Ratio: Soothsayer for Outcome in Sepsis
title_full_unstemmed Serum Lactate-Albumin Ratio: Soothsayer for Outcome in Sepsis
title_short Serum Lactate-Albumin Ratio: Soothsayer for Outcome in Sepsis
title_sort serum lactate-albumin ratio: soothsayer for outcome in sepsis
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146386/
https://www.ncbi.nlm.nih.gov/pubmed/37123772
http://dx.doi.org/10.7759/cureus.36816
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