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An Integrated Multidisciplinary Circuit Led by Hospital and Community Pharmacists to Implement Clopidogrel Pharmacogenetics in Clinical Practice

The use of pharmacogenetics to optimize pharmacotherapy is growing rapidly. This study evaluates the feasibility and operability of a collaborative circuit involving hospital and community pharmacists to implement clopidogrel pharmacogenetics in Barcelona, Catalonia, Spain. We aimed to enroll patien...

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Autores principales: Mir, Joan Francesc, Rodríguez-Caba, Cristina, Estrada-Campmany, Maria, Fernández de Gamarra-Martínez, Edurne, Mangues, Maria Antònia, Bagaría, Guillermo, Riera, Pau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146470/
https://www.ncbi.nlm.nih.gov/pubmed/37104082
http://dx.doi.org/10.3390/pharmacy11020076
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author Mir, Joan Francesc
Rodríguez-Caba, Cristina
Estrada-Campmany, Maria
Fernández de Gamarra-Martínez, Edurne
Mangues, Maria Antònia
Bagaría, Guillermo
Riera, Pau
author_facet Mir, Joan Francesc
Rodríguez-Caba, Cristina
Estrada-Campmany, Maria
Fernández de Gamarra-Martínez, Edurne
Mangues, Maria Antònia
Bagaría, Guillermo
Riera, Pau
author_sort Mir, Joan Francesc
collection PubMed
description The use of pharmacogenetics to optimize pharmacotherapy is growing rapidly. This study evaluates the feasibility and operability of a collaborative circuit involving hospital and community pharmacists to implement clopidogrel pharmacogenetics in Barcelona, Catalonia, Spain. We aimed to enroll patients with a clopidogrel prescription from cardiologists at the collaborating hospital. Community pharmacists collected patients’ pharmacotherapeutic profiles and saliva samples, which were then sent to the hospital for CYP2C19 genotyping. Hospital pharmacists collated the obtained data with patients’ clinical records. Data were analyzed jointly with a cardiologist to assess the suitability of clopidogrel. The provincial pharmacists’ association coordinated the project and provided IT and logistic support. The study began in January 2020. However, it was suspended in March 2020 due to the COVID-19 pandemic. At that moment, 120 patients had been assessed, 16 of whom met the inclusion criteria and were enrolled in the study. The processing of samples obtained before the pandemic had an average delay of 13.8 ± 5.4 days. A total of 37.5% patients were intermediate metabolizers and 18.8% were ultrarapid metabolizers. No poor metabolizers were detected. Pharmacists rated their experience with a 7.3 ± 2.7 likelihood of recommending that fellow pharmacists participate. The net promoter score among participating pharmacists was +10%. Our results show that the circuit is feasible and operable for further initiatives.
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spelling pubmed-101464702023-04-29 An Integrated Multidisciplinary Circuit Led by Hospital and Community Pharmacists to Implement Clopidogrel Pharmacogenetics in Clinical Practice Mir, Joan Francesc Rodríguez-Caba, Cristina Estrada-Campmany, Maria Fernández de Gamarra-Martínez, Edurne Mangues, Maria Antònia Bagaría, Guillermo Riera, Pau Pharmacy (Basel) Article The use of pharmacogenetics to optimize pharmacotherapy is growing rapidly. This study evaluates the feasibility and operability of a collaborative circuit involving hospital and community pharmacists to implement clopidogrel pharmacogenetics in Barcelona, Catalonia, Spain. We aimed to enroll patients with a clopidogrel prescription from cardiologists at the collaborating hospital. Community pharmacists collected patients’ pharmacotherapeutic profiles and saliva samples, which were then sent to the hospital for CYP2C19 genotyping. Hospital pharmacists collated the obtained data with patients’ clinical records. Data were analyzed jointly with a cardiologist to assess the suitability of clopidogrel. The provincial pharmacists’ association coordinated the project and provided IT and logistic support. The study began in January 2020. However, it was suspended in March 2020 due to the COVID-19 pandemic. At that moment, 120 patients had been assessed, 16 of whom met the inclusion criteria and were enrolled in the study. The processing of samples obtained before the pandemic had an average delay of 13.8 ± 5.4 days. A total of 37.5% patients were intermediate metabolizers and 18.8% were ultrarapid metabolizers. No poor metabolizers were detected. Pharmacists rated their experience with a 7.3 ± 2.7 likelihood of recommending that fellow pharmacists participate. The net promoter score among participating pharmacists was +10%. Our results show that the circuit is feasible and operable for further initiatives. MDPI 2023-04-17 /pmc/articles/PMC10146470/ /pubmed/37104082 http://dx.doi.org/10.3390/pharmacy11020076 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mir, Joan Francesc
Rodríguez-Caba, Cristina
Estrada-Campmany, Maria
Fernández de Gamarra-Martínez, Edurne
Mangues, Maria Antònia
Bagaría, Guillermo
Riera, Pau
An Integrated Multidisciplinary Circuit Led by Hospital and Community Pharmacists to Implement Clopidogrel Pharmacogenetics in Clinical Practice
title An Integrated Multidisciplinary Circuit Led by Hospital and Community Pharmacists to Implement Clopidogrel Pharmacogenetics in Clinical Practice
title_full An Integrated Multidisciplinary Circuit Led by Hospital and Community Pharmacists to Implement Clopidogrel Pharmacogenetics in Clinical Practice
title_fullStr An Integrated Multidisciplinary Circuit Led by Hospital and Community Pharmacists to Implement Clopidogrel Pharmacogenetics in Clinical Practice
title_full_unstemmed An Integrated Multidisciplinary Circuit Led by Hospital and Community Pharmacists to Implement Clopidogrel Pharmacogenetics in Clinical Practice
title_short An Integrated Multidisciplinary Circuit Led by Hospital and Community Pharmacists to Implement Clopidogrel Pharmacogenetics in Clinical Practice
title_sort integrated multidisciplinary circuit led by hospital and community pharmacists to implement clopidogrel pharmacogenetics in clinical practice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146470/
https://www.ncbi.nlm.nih.gov/pubmed/37104082
http://dx.doi.org/10.3390/pharmacy11020076
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