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Comparison of 116 Radiosurgery Treatment Plans for Multi-Leaf and Cone Collimator on a Varian Edge Linac: Are Cones Superior in the Daily Routine?

Delivering focused radiation doses via linear accelerators is a crucial component of stereotactic radiosurgery (SRS) for brain metastases. The Varian Edge linear accelerator provides highly conformal radiation therapy through a high-definition multi-leaf collimator (HD120 MLC) and conical collimator...

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Autores principales: Čehobašić, Adlan, Paladino, Josip, Kaučić, Hrvoje, Mišir-Krpan, Ana, Leipold, Vanda, Mlinarić, Mihaela, Kosmina, Domagoj, Mack, Andreas, Schwarz, Dragan, Divošević, Sunčana, Alerić, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146576/
https://www.ncbi.nlm.nih.gov/pubmed/37109549
http://dx.doi.org/10.3390/life13041020
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author Čehobašić, Adlan
Paladino, Josip
Kaučić, Hrvoje
Mišir-Krpan, Ana
Leipold, Vanda
Mlinarić, Mihaela
Kosmina, Domagoj
Mack, Andreas
Schwarz, Dragan
Divošević, Sunčana
Alerić, Ivana
author_facet Čehobašić, Adlan
Paladino, Josip
Kaučić, Hrvoje
Mišir-Krpan, Ana
Leipold, Vanda
Mlinarić, Mihaela
Kosmina, Domagoj
Mack, Andreas
Schwarz, Dragan
Divošević, Sunčana
Alerić, Ivana
author_sort Čehobašić, Adlan
collection PubMed
description Delivering focused radiation doses via linear accelerators is a crucial component of stereotactic radiosurgery (SRS) for brain metastases. The Varian Edge linear accelerator provides highly conformal radiation therapy through a high-definition multi-leaf collimator (HD120 MLC) and conical collimator (CC). HD120 MLC adapts to the shape of the target volume using movable tungsten leaves, while CC has a block of conical shape (cones). CC in SRS treatments of small brain metastases is preferred due to its mechanical stability and steeper dose fall-off, potentially sparing organs at risk (OARs) and the brain better than HD120 MLC. This study aims to determine if CC offers significant advantages over HD120 MLC for SRS treatments. For 116 metastatic lesions, CC and HD120 MLC treatment plans were created in Varian Eclipse TPS and compared based on various dose parameters, robustness tests, and QA measurements. The results indicate that CC provides no significant advantages over HD120 MLC, except for slight, clinically insignificant benefits in brain sparing and dose fall-off for the smallest lesions. HD120 MLC outperforms CC in almost every aspect, making it a better choice for irradiating brain metastases with 0.1 cm(3) or higher volumes.
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spelling pubmed-101465762023-04-29 Comparison of 116 Radiosurgery Treatment Plans for Multi-Leaf and Cone Collimator on a Varian Edge Linac: Are Cones Superior in the Daily Routine? Čehobašić, Adlan Paladino, Josip Kaučić, Hrvoje Mišir-Krpan, Ana Leipold, Vanda Mlinarić, Mihaela Kosmina, Domagoj Mack, Andreas Schwarz, Dragan Divošević, Sunčana Alerić, Ivana Life (Basel) Article Delivering focused radiation doses via linear accelerators is a crucial component of stereotactic radiosurgery (SRS) for brain metastases. The Varian Edge linear accelerator provides highly conformal radiation therapy through a high-definition multi-leaf collimator (HD120 MLC) and conical collimator (CC). HD120 MLC adapts to the shape of the target volume using movable tungsten leaves, while CC has a block of conical shape (cones). CC in SRS treatments of small brain metastases is preferred due to its mechanical stability and steeper dose fall-off, potentially sparing organs at risk (OARs) and the brain better than HD120 MLC. This study aims to determine if CC offers significant advantages over HD120 MLC for SRS treatments. For 116 metastatic lesions, CC and HD120 MLC treatment plans were created in Varian Eclipse TPS and compared based on various dose parameters, robustness tests, and QA measurements. The results indicate that CC provides no significant advantages over HD120 MLC, except for slight, clinically insignificant benefits in brain sparing and dose fall-off for the smallest lesions. HD120 MLC outperforms CC in almost every aspect, making it a better choice for irradiating brain metastases with 0.1 cm(3) or higher volumes. MDPI 2023-04-15 /pmc/articles/PMC10146576/ /pubmed/37109549 http://dx.doi.org/10.3390/life13041020 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Čehobašić, Adlan
Paladino, Josip
Kaučić, Hrvoje
Mišir-Krpan, Ana
Leipold, Vanda
Mlinarić, Mihaela
Kosmina, Domagoj
Mack, Andreas
Schwarz, Dragan
Divošević, Sunčana
Alerić, Ivana
Comparison of 116 Radiosurgery Treatment Plans for Multi-Leaf and Cone Collimator on a Varian Edge Linac: Are Cones Superior in the Daily Routine?
title Comparison of 116 Radiosurgery Treatment Plans for Multi-Leaf and Cone Collimator on a Varian Edge Linac: Are Cones Superior in the Daily Routine?
title_full Comparison of 116 Radiosurgery Treatment Plans for Multi-Leaf and Cone Collimator on a Varian Edge Linac: Are Cones Superior in the Daily Routine?
title_fullStr Comparison of 116 Radiosurgery Treatment Plans for Multi-Leaf and Cone Collimator on a Varian Edge Linac: Are Cones Superior in the Daily Routine?
title_full_unstemmed Comparison of 116 Radiosurgery Treatment Plans for Multi-Leaf and Cone Collimator on a Varian Edge Linac: Are Cones Superior in the Daily Routine?
title_short Comparison of 116 Radiosurgery Treatment Plans for Multi-Leaf and Cone Collimator on a Varian Edge Linac: Are Cones Superior in the Daily Routine?
title_sort comparison of 116 radiosurgery treatment plans for multi-leaf and cone collimator on a varian edge linac: are cones superior in the daily routine?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146576/
https://www.ncbi.nlm.nih.gov/pubmed/37109549
http://dx.doi.org/10.3390/life13041020
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