Overexpression of a Short Sulfonylurea Splice Variant Increases Cardiac Glucose Uptake and Uncouples Mitochondria by Regulating ROMK Activity

The mitochondrial splice variant of the sulfonylurea receptor (SUR2A-55) is associated with protection from myocardial ischemia-reperfusion (IR) injury, increased mitochondrial ATP sensitive K(+) channel activity (mitoK(ATP)) and altered glucose metabolism. While mitoK(ATP) channels composed of CCDC...

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Detalles Bibliográficos
Autores principales: El-Meanawy, Sarah K., Dooge, Holly, Wexler, Allison C., Kosmach, Anna C., Serban, Lara, Santos, Elizabeth A., Alvarado, Francisco J., Hacker, Timothy A., Ramratnam, Mohun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146620/
https://www.ncbi.nlm.nih.gov/pubmed/37109544
http://dx.doi.org/10.3390/life13041015

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