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Abies holophylla Leaf Essential Oil Alleviates Allergic Rhinitis Based on Network Pharmacology

Abies holophylla is an evergreen coniferous species that has been widely used for treating pulmonary diseases and colds. Previous research has demonstrated the anti-inflammatory effect of Abies species and the anti-asthmatic activities of Abies holophylla leaf essential oil (AEO). As asthma and alle...

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Autores principales: Chung, Jae Yoon, Park, Nayoung, Kim, Mi Hye, Yang, Woong Mo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146622/
https://www.ncbi.nlm.nih.gov/pubmed/37111680
http://dx.doi.org/10.3390/pharmaceutics15041195
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author Chung, Jae Yoon
Park, Nayoung
Kim, Mi Hye
Yang, Woong Mo
author_facet Chung, Jae Yoon
Park, Nayoung
Kim, Mi Hye
Yang, Woong Mo
author_sort Chung, Jae Yoon
collection PubMed
description Abies holophylla is an evergreen coniferous species that has been widely used for treating pulmonary diseases and colds. Previous research has demonstrated the anti-inflammatory effect of Abies species and the anti-asthmatic activities of Abies holophylla leaf essential oil (AEO). As asthma and allergic rhinitis (AR) share pathophysiology and pharmacotherapeutic interventions, AEO inhalation can also ameliorate upper respiratory allergic diseases. This study explored the protective effects of AEO on AR with network pharmacological pathway prediction. The potential target pathways of AEO were analyzed by a network pharmacological approach. The BALB/c mice were sensitized by ovalbumin (OVA) and 10 μm particular matter (PM(10)) to induce allergic rhinitis. Aerosolized AEO 0.0003% and 0.03% were delivered by nebulizer for 5 min a day, 3 times a week for 7 weeks. Nasal symptoms (sneezing and rubbing), histopathological changes in nasal tissues, serum IgE, and zonula occludens-1 (ZO-1) expressions on nasal tissues were analyzed. After AR induction with OVA+PM(10) and inhalation of AEO 0.0003% and 0.03% treatment, AEO significantly decreased allergic symptoms (sneezing and rubbing), hyperplasia of nasal epithelial thickness, goblet cell counts, and serum IgE level. The network analysis demonstrated that the possible molecular mechanism of AEO is highly associated with the IL-17 signaling pathway and tight junction. The target pathway of AEO was investigated in RPMI 2650 nasal epithelial cells. Treatment of AEO on PM(10)-treated nasal epithelial cells significantly reduced the production of inflammatory mediators related to the IL-17 signaling pathway, NF-κB, and the MAPK signaling pathway and prevented the reduction in TJ-related factors. When taken together, AEO inhalation may be considered as a potential treatment for AR by alleviating nasal inflammation and recovering the tight junction.
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spelling pubmed-101466222023-04-29 Abies holophylla Leaf Essential Oil Alleviates Allergic Rhinitis Based on Network Pharmacology Chung, Jae Yoon Park, Nayoung Kim, Mi Hye Yang, Woong Mo Pharmaceutics Article Abies holophylla is an evergreen coniferous species that has been widely used for treating pulmonary diseases and colds. Previous research has demonstrated the anti-inflammatory effect of Abies species and the anti-asthmatic activities of Abies holophylla leaf essential oil (AEO). As asthma and allergic rhinitis (AR) share pathophysiology and pharmacotherapeutic interventions, AEO inhalation can also ameliorate upper respiratory allergic diseases. This study explored the protective effects of AEO on AR with network pharmacological pathway prediction. The potential target pathways of AEO were analyzed by a network pharmacological approach. The BALB/c mice were sensitized by ovalbumin (OVA) and 10 μm particular matter (PM(10)) to induce allergic rhinitis. Aerosolized AEO 0.0003% and 0.03% were delivered by nebulizer for 5 min a day, 3 times a week for 7 weeks. Nasal symptoms (sneezing and rubbing), histopathological changes in nasal tissues, serum IgE, and zonula occludens-1 (ZO-1) expressions on nasal tissues were analyzed. After AR induction with OVA+PM(10) and inhalation of AEO 0.0003% and 0.03% treatment, AEO significantly decreased allergic symptoms (sneezing and rubbing), hyperplasia of nasal epithelial thickness, goblet cell counts, and serum IgE level. The network analysis demonstrated that the possible molecular mechanism of AEO is highly associated with the IL-17 signaling pathway and tight junction. The target pathway of AEO was investigated in RPMI 2650 nasal epithelial cells. Treatment of AEO on PM(10)-treated nasal epithelial cells significantly reduced the production of inflammatory mediators related to the IL-17 signaling pathway, NF-κB, and the MAPK signaling pathway and prevented the reduction in TJ-related factors. When taken together, AEO inhalation may be considered as a potential treatment for AR by alleviating nasal inflammation and recovering the tight junction. MDPI 2023-04-09 /pmc/articles/PMC10146622/ /pubmed/37111680 http://dx.doi.org/10.3390/pharmaceutics15041195 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chung, Jae Yoon
Park, Nayoung
Kim, Mi Hye
Yang, Woong Mo
Abies holophylla Leaf Essential Oil Alleviates Allergic Rhinitis Based on Network Pharmacology
title Abies holophylla Leaf Essential Oil Alleviates Allergic Rhinitis Based on Network Pharmacology
title_full Abies holophylla Leaf Essential Oil Alleviates Allergic Rhinitis Based on Network Pharmacology
title_fullStr Abies holophylla Leaf Essential Oil Alleviates Allergic Rhinitis Based on Network Pharmacology
title_full_unstemmed Abies holophylla Leaf Essential Oil Alleviates Allergic Rhinitis Based on Network Pharmacology
title_short Abies holophylla Leaf Essential Oil Alleviates Allergic Rhinitis Based on Network Pharmacology
title_sort abies holophylla leaf essential oil alleviates allergic rhinitis based on network pharmacology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146622/
https://www.ncbi.nlm.nih.gov/pubmed/37111680
http://dx.doi.org/10.3390/pharmaceutics15041195
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