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Asymptomatic and Mild SARS-CoV-2 Infections in a Hungarian Outpatient Cohort in the First Year of the COVID-19 Pandemic
We aimed to estimate the proportion of the population infected with SARS-CoV-2 in the first year of the pandemic. The study population consisted of outpatient adults with mild or no COVID-19 symptoms and was divided into subpopulations with different levels of exposure. Among the subpopulation witho...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146718/ https://www.ncbi.nlm.nih.gov/pubmed/37104330 http://dx.doi.org/10.3390/tropicalmed8040204 |
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author | Jankovics, István Müller, Cecília Gönczöl, Éva Visontai, Ildikó Varga, István Lőrincz, Márta Kuti, Dávid Hasitz, Ágnes Malik, Péter Ursu, Krisztina Bányász, Borbála Sarkadi, Júlia Dénes, Béla |
author_facet | Jankovics, István Müller, Cecília Gönczöl, Éva Visontai, Ildikó Varga, István Lőrincz, Márta Kuti, Dávid Hasitz, Ágnes Malik, Péter Ursu, Krisztina Bányász, Borbála Sarkadi, Júlia Dénes, Béla |
author_sort | Jankovics, István |
collection | PubMed |
description | We aimed to estimate the proportion of the population infected with SARS-CoV-2 in the first year of the pandemic. The study population consisted of outpatient adults with mild or no COVID-19 symptoms and was divided into subpopulations with different levels of exposure. Among the subpopulation without known previous COVID-19 contacts, 4143 patients were investigated. Of the subpopulation with known COVID-19 contacts, 594 patients were investigated. IgG- and IgA-seroprevalence and RT-PCR positivity were determined in context with COVID-19 symptoms. Our results suggested no significant age-related differences between participants for IgG positivity but indicated that COVID-19 symptoms occurred most frequently in people aged between 20 and 29 years. Depending on the study population, 23.4–74.0% PCR-positive people (who were symptomless SARS-CoV-2 carriers at the time of the investigation) were identified. It was also observed that 72.7% of the patients remained seronegative for 30 days or more after their first PCR-positive results. This study hoped to contribute to the scientific understanding of the significance of asymptomatic and mild infections in the long persistence of the pandemic. |
format | Online Article Text |
id | pubmed-10146718 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101467182023-04-29 Asymptomatic and Mild SARS-CoV-2 Infections in a Hungarian Outpatient Cohort in the First Year of the COVID-19 Pandemic Jankovics, István Müller, Cecília Gönczöl, Éva Visontai, Ildikó Varga, István Lőrincz, Márta Kuti, Dávid Hasitz, Ágnes Malik, Péter Ursu, Krisztina Bányász, Borbála Sarkadi, Júlia Dénes, Béla Trop Med Infect Dis Article We aimed to estimate the proportion of the population infected with SARS-CoV-2 in the first year of the pandemic. The study population consisted of outpatient adults with mild or no COVID-19 symptoms and was divided into subpopulations with different levels of exposure. Among the subpopulation without known previous COVID-19 contacts, 4143 patients were investigated. Of the subpopulation with known COVID-19 contacts, 594 patients were investigated. IgG- and IgA-seroprevalence and RT-PCR positivity were determined in context with COVID-19 symptoms. Our results suggested no significant age-related differences between participants for IgG positivity but indicated that COVID-19 symptoms occurred most frequently in people aged between 20 and 29 years. Depending on the study population, 23.4–74.0% PCR-positive people (who were symptomless SARS-CoV-2 carriers at the time of the investigation) were identified. It was also observed that 72.7% of the patients remained seronegative for 30 days or more after their first PCR-positive results. This study hoped to contribute to the scientific understanding of the significance of asymptomatic and mild infections in the long persistence of the pandemic. MDPI 2023-03-29 /pmc/articles/PMC10146718/ /pubmed/37104330 http://dx.doi.org/10.3390/tropicalmed8040204 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jankovics, István Müller, Cecília Gönczöl, Éva Visontai, Ildikó Varga, István Lőrincz, Márta Kuti, Dávid Hasitz, Ágnes Malik, Péter Ursu, Krisztina Bányász, Borbála Sarkadi, Júlia Dénes, Béla Asymptomatic and Mild SARS-CoV-2 Infections in a Hungarian Outpatient Cohort in the First Year of the COVID-19 Pandemic |
title | Asymptomatic and Mild SARS-CoV-2 Infections in a Hungarian Outpatient Cohort in the First Year of the COVID-19 Pandemic |
title_full | Asymptomatic and Mild SARS-CoV-2 Infections in a Hungarian Outpatient Cohort in the First Year of the COVID-19 Pandemic |
title_fullStr | Asymptomatic and Mild SARS-CoV-2 Infections in a Hungarian Outpatient Cohort in the First Year of the COVID-19 Pandemic |
title_full_unstemmed | Asymptomatic and Mild SARS-CoV-2 Infections in a Hungarian Outpatient Cohort in the First Year of the COVID-19 Pandemic |
title_short | Asymptomatic and Mild SARS-CoV-2 Infections in a Hungarian Outpatient Cohort in the First Year of the COVID-19 Pandemic |
title_sort | asymptomatic and mild sars-cov-2 infections in a hungarian outpatient cohort in the first year of the covid-19 pandemic |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146718/ https://www.ncbi.nlm.nih.gov/pubmed/37104330 http://dx.doi.org/10.3390/tropicalmed8040204 |
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