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Asymptomatic and Mild SARS-CoV-2 Infections in a Hungarian Outpatient Cohort in the First Year of the COVID-19 Pandemic

We aimed to estimate the proportion of the population infected with SARS-CoV-2 in the first year of the pandemic. The study population consisted of outpatient adults with mild or no COVID-19 symptoms and was divided into subpopulations with different levels of exposure. Among the subpopulation witho...

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Autores principales: Jankovics, István, Müller, Cecília, Gönczöl, Éva, Visontai, Ildikó, Varga, István, Lőrincz, Márta, Kuti, Dávid, Hasitz, Ágnes, Malik, Péter, Ursu, Krisztina, Bányász, Borbála, Sarkadi, Júlia, Dénes, Béla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146718/
https://www.ncbi.nlm.nih.gov/pubmed/37104330
http://dx.doi.org/10.3390/tropicalmed8040204
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author Jankovics, István
Müller, Cecília
Gönczöl, Éva
Visontai, Ildikó
Varga, István
Lőrincz, Márta
Kuti, Dávid
Hasitz, Ágnes
Malik, Péter
Ursu, Krisztina
Bányász, Borbála
Sarkadi, Júlia
Dénes, Béla
author_facet Jankovics, István
Müller, Cecília
Gönczöl, Éva
Visontai, Ildikó
Varga, István
Lőrincz, Márta
Kuti, Dávid
Hasitz, Ágnes
Malik, Péter
Ursu, Krisztina
Bányász, Borbála
Sarkadi, Júlia
Dénes, Béla
author_sort Jankovics, István
collection PubMed
description We aimed to estimate the proportion of the population infected with SARS-CoV-2 in the first year of the pandemic. The study population consisted of outpatient adults with mild or no COVID-19 symptoms and was divided into subpopulations with different levels of exposure. Among the subpopulation without known previous COVID-19 contacts, 4143 patients were investigated. Of the subpopulation with known COVID-19 contacts, 594 patients were investigated. IgG- and IgA-seroprevalence and RT-PCR positivity were determined in context with COVID-19 symptoms. Our results suggested no significant age-related differences between participants for IgG positivity but indicated that COVID-19 symptoms occurred most frequently in people aged between 20 and 29 years. Depending on the study population, 23.4–74.0% PCR-positive people (who were symptomless SARS-CoV-2 carriers at the time of the investigation) were identified. It was also observed that 72.7% of the patients remained seronegative for 30 days or more after their first PCR-positive results. This study hoped to contribute to the scientific understanding of the significance of asymptomatic and mild infections in the long persistence of the pandemic.
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spelling pubmed-101467182023-04-29 Asymptomatic and Mild SARS-CoV-2 Infections in a Hungarian Outpatient Cohort in the First Year of the COVID-19 Pandemic Jankovics, István Müller, Cecília Gönczöl, Éva Visontai, Ildikó Varga, István Lőrincz, Márta Kuti, Dávid Hasitz, Ágnes Malik, Péter Ursu, Krisztina Bányász, Borbála Sarkadi, Júlia Dénes, Béla Trop Med Infect Dis Article We aimed to estimate the proportion of the population infected with SARS-CoV-2 in the first year of the pandemic. The study population consisted of outpatient adults with mild or no COVID-19 symptoms and was divided into subpopulations with different levels of exposure. Among the subpopulation without known previous COVID-19 contacts, 4143 patients were investigated. Of the subpopulation with known COVID-19 contacts, 594 patients were investigated. IgG- and IgA-seroprevalence and RT-PCR positivity were determined in context with COVID-19 symptoms. Our results suggested no significant age-related differences between participants for IgG positivity but indicated that COVID-19 symptoms occurred most frequently in people aged between 20 and 29 years. Depending on the study population, 23.4–74.0% PCR-positive people (who were symptomless SARS-CoV-2 carriers at the time of the investigation) were identified. It was also observed that 72.7% of the patients remained seronegative for 30 days or more after their first PCR-positive results. This study hoped to contribute to the scientific understanding of the significance of asymptomatic and mild infections in the long persistence of the pandemic. MDPI 2023-03-29 /pmc/articles/PMC10146718/ /pubmed/37104330 http://dx.doi.org/10.3390/tropicalmed8040204 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jankovics, István
Müller, Cecília
Gönczöl, Éva
Visontai, Ildikó
Varga, István
Lőrincz, Márta
Kuti, Dávid
Hasitz, Ágnes
Malik, Péter
Ursu, Krisztina
Bányász, Borbála
Sarkadi, Júlia
Dénes, Béla
Asymptomatic and Mild SARS-CoV-2 Infections in a Hungarian Outpatient Cohort in the First Year of the COVID-19 Pandemic
title Asymptomatic and Mild SARS-CoV-2 Infections in a Hungarian Outpatient Cohort in the First Year of the COVID-19 Pandemic
title_full Asymptomatic and Mild SARS-CoV-2 Infections in a Hungarian Outpatient Cohort in the First Year of the COVID-19 Pandemic
title_fullStr Asymptomatic and Mild SARS-CoV-2 Infections in a Hungarian Outpatient Cohort in the First Year of the COVID-19 Pandemic
title_full_unstemmed Asymptomatic and Mild SARS-CoV-2 Infections in a Hungarian Outpatient Cohort in the First Year of the COVID-19 Pandemic
title_short Asymptomatic and Mild SARS-CoV-2 Infections in a Hungarian Outpatient Cohort in the First Year of the COVID-19 Pandemic
title_sort asymptomatic and mild sars-cov-2 infections in a hungarian outpatient cohort in the first year of the covid-19 pandemic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146718/
https://www.ncbi.nlm.nih.gov/pubmed/37104330
http://dx.doi.org/10.3390/tropicalmed8040204
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