Leveraging Hot Spots of TEAD–Coregulator Interactions in the Design of Direct Small Molecule Protein-Protein Interaction Disruptors Targeting Hippo Pathway Signaling

The Hippo signaling pathway is a highly conserved pathway that plays important roles in the regulation of cell proliferation and apoptosis. Transcription factors TEAD1-4 and transcriptional coregulators YAP/TAZ are the downstream effectors of the Hippo pathway and can modulate Hippo biology. Dysregu...

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Detalles Bibliográficos
Autores principales: Zhao, Bin, Pobbati, Ajaybabu V., Rubin, Brian P., Stauffer, Shaun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146773/
https://www.ncbi.nlm.nih.gov/pubmed/37111340
http://dx.doi.org/10.3390/ph16040583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146773/
https://www.ncbi.nlm.nih.gov/pubmed/37111340
http://dx.doi.org/10.3390/ph16040583

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