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Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action

Curcumin, one of the major ingredients of turmeric (Curcuma longa), has been widely reported for its diverse bioactivities, including against malaria and inflammatory-related diseases. However, curcumin’s low bioavailability limits its potential as an antimalarial and anti-inflammatory agent. Theref...

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Autores principales: Jamil, Siti Nur Hidayah, Ali, Amatul Hamizah, Feroz, Shevin Rizal, Lam, Su Datt, Agustar, Hani Kartini, Mohd Abd Razak, Mohd Ridzuan, Latip, Jalifah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146798/
https://www.ncbi.nlm.nih.gov/pubmed/37111366
http://dx.doi.org/10.3390/ph16040609
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author Jamil, Siti Nur Hidayah
Ali, Amatul Hamizah
Feroz, Shevin Rizal
Lam, Su Datt
Agustar, Hani Kartini
Mohd Abd Razak, Mohd Ridzuan
Latip, Jalifah
author_facet Jamil, Siti Nur Hidayah
Ali, Amatul Hamizah
Feroz, Shevin Rizal
Lam, Su Datt
Agustar, Hani Kartini
Mohd Abd Razak, Mohd Ridzuan
Latip, Jalifah
author_sort Jamil, Siti Nur Hidayah
collection PubMed
description Curcumin, one of the major ingredients of turmeric (Curcuma longa), has been widely reported for its diverse bioactivities, including against malaria and inflammatory-related diseases. However, curcumin’s low bioavailability limits its potential as an antimalarial and anti-inflammatory agent. Therefore, research on the design and synthesis of novel curcumin derivatives is being actively pursued to improve the pharmacokinetic profile and efficacy of curcumin. This review discusses the antimalarial and anti-inflammatory activities and the structure–activity relationship (SAR), as well as the mechanisms of action of curcumin and its derivatives in malarial treatment. This review provides information on the identification of the methoxy phenyl group responsible for the antimalarial activity and the potential sites and functional groups of curcumin for structural modification to improve its antimalarial and anti-inflammatory actions, as well as potential molecular targets of curcumin derivatives in the context of malaria and inflammation.
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spelling pubmed-101467982023-04-29 Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action Jamil, Siti Nur Hidayah Ali, Amatul Hamizah Feroz, Shevin Rizal Lam, Su Datt Agustar, Hani Kartini Mohd Abd Razak, Mohd Ridzuan Latip, Jalifah Pharmaceuticals (Basel) Review Curcumin, one of the major ingredients of turmeric (Curcuma longa), has been widely reported for its diverse bioactivities, including against malaria and inflammatory-related diseases. However, curcumin’s low bioavailability limits its potential as an antimalarial and anti-inflammatory agent. Therefore, research on the design and synthesis of novel curcumin derivatives is being actively pursued to improve the pharmacokinetic profile and efficacy of curcumin. This review discusses the antimalarial and anti-inflammatory activities and the structure–activity relationship (SAR), as well as the mechanisms of action of curcumin and its derivatives in malarial treatment. This review provides information on the identification of the methoxy phenyl group responsible for the antimalarial activity and the potential sites and functional groups of curcumin for structural modification to improve its antimalarial and anti-inflammatory actions, as well as potential molecular targets of curcumin derivatives in the context of malaria and inflammation. MDPI 2023-04-18 /pmc/articles/PMC10146798/ /pubmed/37111366 http://dx.doi.org/10.3390/ph16040609 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jamil, Siti Nur Hidayah
Ali, Amatul Hamizah
Feroz, Shevin Rizal
Lam, Su Datt
Agustar, Hani Kartini
Mohd Abd Razak, Mohd Ridzuan
Latip, Jalifah
Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action
title Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action
title_full Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action
title_fullStr Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action
title_full_unstemmed Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action
title_short Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action
title_sort curcumin and its derivatives as potential antimalarial and anti-inflammatory agents: a review on structure–activity relationship and mechanism of action
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146798/
https://www.ncbi.nlm.nih.gov/pubmed/37111366
http://dx.doi.org/10.3390/ph16040609
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