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The Omicron Lineages BA.1 and BA.2 (Betacoronavirus SARS-CoV-2) Have Repeatedly Entered Brazil through a Single Dispersal Hub
Brazil currently ranks second in absolute deaths by COVID-19, even though most of its population has completed the vaccination protocol. With the introduction of Omicron in late 2021, the number of COVID-19 cases soared once again in the country. We investigated in this work how lineages BA.1 and BA...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146814/ https://www.ncbi.nlm.nih.gov/pubmed/37112869 http://dx.doi.org/10.3390/v15040888 |
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| author | Lamarca, Alessandra P. de Souza, Ueric José Borges Moreira, Filipe Romero Rebello de Almeida, Luiz G. P. de Menezes, Mariane Talon de Souza, Adrieli Barboza Ferreira, Alessandro Clayton de Souza Gerber, Alexandra L. de Lima, Aline B. Guimarães, Ana Paula de C. Cavalcanti, Andréa Cony Silva, Aryel B. Paz e Lima, Bruna Israel Lobato, Cirley Silva, Cristiane Gomes Da Mendonça, Cristiane P. T. B. Queiroz, Daniel Costa Zauli, Danielle Alves Gomes Menezes, Diego Possebon, Fábio Sossai Cardoso, Franciano Dias Pereira Malta, Frederico Scott Varella Braga-Paz, Isabela Silva, Joice do Prado Ferreira, Jorge Gomes Goulart Galvão, Jucimária Dantas de Souza, Leandro Magalhães Ferreira, Leonardo Possuelo, Lia Gonçalves Cavalcante, Liliane Tavares de Faria Alvim, Luige B. de Souza, Luiz Fellype Alves Santos, Luiza C. G. de Araújo E Dias, Rillery Calixto Souza, Rutilene Barbosa Castro, Thaís Regina y Valim, Andréia Rosane de Moura Campos, Fabrício Souza Araujo, João Pessoa Trindade, Priscila de Arruda Aguiar, Renato S. Michael Delai, Robson de Vasconcelos, Ana Tereza R |
| author_facet | Lamarca, Alessandra P. de Souza, Ueric José Borges Moreira, Filipe Romero Rebello de Almeida, Luiz G. P. de Menezes, Mariane Talon de Souza, Adrieli Barboza Ferreira, Alessandro Clayton de Souza Gerber, Alexandra L. de Lima, Aline B. Guimarães, Ana Paula de C. Cavalcanti, Andréa Cony Silva, Aryel B. Paz e Lima, Bruna Israel Lobato, Cirley Silva, Cristiane Gomes Da Mendonça, Cristiane P. T. B. Queiroz, Daniel Costa Zauli, Danielle Alves Gomes Menezes, Diego Possebon, Fábio Sossai Cardoso, Franciano Dias Pereira Malta, Frederico Scott Varella Braga-Paz, Isabela Silva, Joice do Prado Ferreira, Jorge Gomes Goulart Galvão, Jucimária Dantas de Souza, Leandro Magalhães Ferreira, Leonardo Possuelo, Lia Gonçalves Cavalcante, Liliane Tavares de Faria Alvim, Luige B. de Souza, Luiz Fellype Alves Santos, Luiza C. G. de Araújo E Dias, Rillery Calixto Souza, Rutilene Barbosa Castro, Thaís Regina y Valim, Andréia Rosane de Moura Campos, Fabrício Souza Araujo, João Pessoa Trindade, Priscila de Arruda Aguiar, Renato S. Michael Delai, Robson de Vasconcelos, Ana Tereza R |
| author_sort | Lamarca, Alessandra P. |
| collection | PubMed |
| description | Brazil currently ranks second in absolute deaths by COVID-19, even though most of its population has completed the vaccination protocol. With the introduction of Omicron in late 2021, the number of COVID-19 cases soared once again in the country. We investigated in this work how lineages BA.1 and BA.2 entered and spread in the country by sequencing 2173 new SARS-CoV-2 genomes collected between October 2021 and April 2022 and analyzing them in addition to more than 18,000 publicly available sequences with phylodynamic methods. We registered that Omicron was present in Brazil as early as 16 November 2021 and by January 2022 was already more than 99% of samples. More importantly, we detected that Omicron has been mostly imported through the state of São Paulo, which in turn dispersed the lineages to other states and regions of Brazil. This knowledge can be used to implement more efficient non-pharmaceutical interventions against the introduction of new SARS-CoV variants focused on surveillance of airports and ground transportation. |
| format | Online Article Text |
| id | pubmed-10146814 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-101468142023-04-29 The Omicron Lineages BA.1 and BA.2 (Betacoronavirus SARS-CoV-2) Have Repeatedly Entered Brazil through a Single Dispersal Hub Lamarca, Alessandra P. de Souza, Ueric José Borges Moreira, Filipe Romero Rebello de Almeida, Luiz G. P. de Menezes, Mariane Talon de Souza, Adrieli Barboza Ferreira, Alessandro Clayton de Souza Gerber, Alexandra L. de Lima, Aline B. Guimarães, Ana Paula de C. Cavalcanti, Andréa Cony Silva, Aryel B. Paz e Lima, Bruna Israel Lobato, Cirley Silva, Cristiane Gomes Da Mendonça, Cristiane P. T. B. Queiroz, Daniel Costa Zauli, Danielle Alves Gomes Menezes, Diego Possebon, Fábio Sossai Cardoso, Franciano Dias Pereira Malta, Frederico Scott Varella Braga-Paz, Isabela Silva, Joice do Prado Ferreira, Jorge Gomes Goulart Galvão, Jucimária Dantas de Souza, Leandro Magalhães Ferreira, Leonardo Possuelo, Lia Gonçalves Cavalcante, Liliane Tavares de Faria Alvim, Luige B. de Souza, Luiz Fellype Alves Santos, Luiza C. G. de Araújo E Dias, Rillery Calixto Souza, Rutilene Barbosa Castro, Thaís Regina y Valim, Andréia Rosane de Moura Campos, Fabrício Souza Araujo, João Pessoa Trindade, Priscila de Arruda Aguiar, Renato S. Michael Delai, Robson de Vasconcelos, Ana Tereza R Viruses Article Brazil currently ranks second in absolute deaths by COVID-19, even though most of its population has completed the vaccination protocol. With the introduction of Omicron in late 2021, the number of COVID-19 cases soared once again in the country. We investigated in this work how lineages BA.1 and BA.2 entered and spread in the country by sequencing 2173 new SARS-CoV-2 genomes collected between October 2021 and April 2022 and analyzing them in addition to more than 18,000 publicly available sequences with phylodynamic methods. We registered that Omicron was present in Brazil as early as 16 November 2021 and by January 2022 was already more than 99% of samples. More importantly, we detected that Omicron has been mostly imported through the state of São Paulo, which in turn dispersed the lineages to other states and regions of Brazil. This knowledge can be used to implement more efficient non-pharmaceutical interventions against the introduction of new SARS-CoV variants focused on surveillance of airports and ground transportation. MDPI 2023-03-30 /pmc/articles/PMC10146814/ /pubmed/37112869 http://dx.doi.org/10.3390/v15040888 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Lamarca, Alessandra P. de Souza, Ueric José Borges Moreira, Filipe Romero Rebello de Almeida, Luiz G. P. de Menezes, Mariane Talon de Souza, Adrieli Barboza Ferreira, Alessandro Clayton de Souza Gerber, Alexandra L. de Lima, Aline B. Guimarães, Ana Paula de C. Cavalcanti, Andréa Cony Silva, Aryel B. Paz e Lima, Bruna Israel Lobato, Cirley Silva, Cristiane Gomes Da Mendonça, Cristiane P. T. B. Queiroz, Daniel Costa Zauli, Danielle Alves Gomes Menezes, Diego Possebon, Fábio Sossai Cardoso, Franciano Dias Pereira Malta, Frederico Scott Varella Braga-Paz, Isabela Silva, Joice do Prado Ferreira, Jorge Gomes Goulart Galvão, Jucimária Dantas de Souza, Leandro Magalhães Ferreira, Leonardo Possuelo, Lia Gonçalves Cavalcante, Liliane Tavares de Faria Alvim, Luige B. de Souza, Luiz Fellype Alves Santos, Luiza C. G. de Araújo E Dias, Rillery Calixto Souza, Rutilene Barbosa Castro, Thaís Regina y Valim, Andréia Rosane de Moura Campos, Fabrício Souza Araujo, João Pessoa Trindade, Priscila de Arruda Aguiar, Renato S. Michael Delai, Robson de Vasconcelos, Ana Tereza R The Omicron Lineages BA.1 and BA.2 (Betacoronavirus SARS-CoV-2) Have Repeatedly Entered Brazil through a Single Dispersal Hub |
| title | The Omicron Lineages BA.1 and BA.2 (Betacoronavirus SARS-CoV-2) Have Repeatedly Entered Brazil through a Single Dispersal Hub |
| title_full | The Omicron Lineages BA.1 and BA.2 (Betacoronavirus SARS-CoV-2) Have Repeatedly Entered Brazil through a Single Dispersal Hub |
| title_fullStr | The Omicron Lineages BA.1 and BA.2 (Betacoronavirus SARS-CoV-2) Have Repeatedly Entered Brazil through a Single Dispersal Hub |
| title_full_unstemmed | The Omicron Lineages BA.1 and BA.2 (Betacoronavirus SARS-CoV-2) Have Repeatedly Entered Brazil through a Single Dispersal Hub |
| title_short | The Omicron Lineages BA.1 and BA.2 (Betacoronavirus SARS-CoV-2) Have Repeatedly Entered Brazil through a Single Dispersal Hub |
| title_sort | omicron lineages ba.1 and ba.2 (betacoronavirus sars-cov-2) have repeatedly entered brazil through a single dispersal hub |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146814/ https://www.ncbi.nlm.nih.gov/pubmed/37112869 http://dx.doi.org/10.3390/v15040888 |
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