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Serum Interleukin 6, Controlling Nutritional Status (CONUT) Score and Phase Angle in Patients with Crohn’s Disease

Crohn’s disease (CD) is a chronic inflammatory disorder that may occur in any segment of the gastrointestinal tract. Asymptomatic or untreated inflammation along with malnutrition can often coexist in patients with CD, impairing clinical outcomes, therefore the aim of this study was to assess the re...

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Autores principales: Cioffi, Iolanda, Scialò, Filippo, Di Vincenzo, Olivia, Gelzo, Monica, Marra, Maurizio, Testa, Anna, Castiglione, Fabiana, Vitale, Maria, Pasanisi, Fabrizio, Santarpia, Lidia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146872/
https://www.ncbi.nlm.nih.gov/pubmed/37111172
http://dx.doi.org/10.3390/nu15081953
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author Cioffi, Iolanda
Scialò, Filippo
Di Vincenzo, Olivia
Gelzo, Monica
Marra, Maurizio
Testa, Anna
Castiglione, Fabiana
Vitale, Maria
Pasanisi, Fabrizio
Santarpia, Lidia
author_facet Cioffi, Iolanda
Scialò, Filippo
Di Vincenzo, Olivia
Gelzo, Monica
Marra, Maurizio
Testa, Anna
Castiglione, Fabiana
Vitale, Maria
Pasanisi, Fabrizio
Santarpia, Lidia
author_sort Cioffi, Iolanda
collection PubMed
description Crohn’s disease (CD) is a chronic inflammatory disorder that may occur in any segment of the gastrointestinal tract. Asymptomatic or untreated inflammation along with malnutrition can often coexist in patients with CD, impairing clinical outcomes, therefore the aim of this study was to assess the relationship between inflammation, malnutrition risk and nutritional status in CD patients. Consecutive adult CD outpatients aged 18-65 years were recruited. Disease activity was clinically defined by the Crohn’s Disease Activity Index (CDAI), whilst anthropometry and phase angle (PhA) were measured. The Controlling Nutritional Status (CONUT) score was retrospectively calculated for screening malnutrition risk and blood samples were taken. A total of 140 CD patients with a mean age of 38.8 ± 13.9 years and an average weight of 64.9 ± 12.0 kg were included. Serum interleukin (IL)-6 concentration was increased in active-CD patients, unrelated to medical treatment, which was associated with CDAI and PhA. Based on the CONUT score, the prevalence of patients with moderate/severe malnutrition risk (score ≥ 5) was 10%, showing lower age, body mass index and fat mass, but higher IL-6 and IL-1β levels than subjects classified as not at risk (score 0–1). Finally, increased IL-6 levels and reduced PhA values were identified as independent predictors of moderate/severe malnutrition risk (p < 0.05). In conclusion, IL-6 increased in active-CD patients, which was inversely correlated with PhA. Although the CONUT score might be helpful for identifying CD patients at moderate/severe risk of malnutrition, larger studies are needed to verify these results in different settings.
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spelling pubmed-101468722023-04-29 Serum Interleukin 6, Controlling Nutritional Status (CONUT) Score and Phase Angle in Patients with Crohn’s Disease Cioffi, Iolanda Scialò, Filippo Di Vincenzo, Olivia Gelzo, Monica Marra, Maurizio Testa, Anna Castiglione, Fabiana Vitale, Maria Pasanisi, Fabrizio Santarpia, Lidia Nutrients Article Crohn’s disease (CD) is a chronic inflammatory disorder that may occur in any segment of the gastrointestinal tract. Asymptomatic or untreated inflammation along with malnutrition can often coexist in patients with CD, impairing clinical outcomes, therefore the aim of this study was to assess the relationship between inflammation, malnutrition risk and nutritional status in CD patients. Consecutive adult CD outpatients aged 18-65 years were recruited. Disease activity was clinically defined by the Crohn’s Disease Activity Index (CDAI), whilst anthropometry and phase angle (PhA) were measured. The Controlling Nutritional Status (CONUT) score was retrospectively calculated for screening malnutrition risk and blood samples were taken. A total of 140 CD patients with a mean age of 38.8 ± 13.9 years and an average weight of 64.9 ± 12.0 kg were included. Serum interleukin (IL)-6 concentration was increased in active-CD patients, unrelated to medical treatment, which was associated with CDAI and PhA. Based on the CONUT score, the prevalence of patients with moderate/severe malnutrition risk (score ≥ 5) was 10%, showing lower age, body mass index and fat mass, but higher IL-6 and IL-1β levels than subjects classified as not at risk (score 0–1). Finally, increased IL-6 levels and reduced PhA values were identified as independent predictors of moderate/severe malnutrition risk (p < 0.05). In conclusion, IL-6 increased in active-CD patients, which was inversely correlated with PhA. Although the CONUT score might be helpful for identifying CD patients at moderate/severe risk of malnutrition, larger studies are needed to verify these results in different settings. MDPI 2023-04-18 /pmc/articles/PMC10146872/ /pubmed/37111172 http://dx.doi.org/10.3390/nu15081953 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cioffi, Iolanda
Scialò, Filippo
Di Vincenzo, Olivia
Gelzo, Monica
Marra, Maurizio
Testa, Anna
Castiglione, Fabiana
Vitale, Maria
Pasanisi, Fabrizio
Santarpia, Lidia
Serum Interleukin 6, Controlling Nutritional Status (CONUT) Score and Phase Angle in Patients with Crohn’s Disease
title Serum Interleukin 6, Controlling Nutritional Status (CONUT) Score and Phase Angle in Patients with Crohn’s Disease
title_full Serum Interleukin 6, Controlling Nutritional Status (CONUT) Score and Phase Angle in Patients with Crohn’s Disease
title_fullStr Serum Interleukin 6, Controlling Nutritional Status (CONUT) Score and Phase Angle in Patients with Crohn’s Disease
title_full_unstemmed Serum Interleukin 6, Controlling Nutritional Status (CONUT) Score and Phase Angle in Patients with Crohn’s Disease
title_short Serum Interleukin 6, Controlling Nutritional Status (CONUT) Score and Phase Angle in Patients with Crohn’s Disease
title_sort serum interleukin 6, controlling nutritional status (conut) score and phase angle in patients with crohn’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146872/
https://www.ncbi.nlm.nih.gov/pubmed/37111172
http://dx.doi.org/10.3390/nu15081953
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