Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy

Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function of IRG1/ITA has been established in multiple pathogen models, but very little is known in cancer. Here, we show that IRG1 is expressed in tum...

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Detalles Bibliográficos
Autores principales: Chen, Yu-Jia, Li, Guan-Nan, Li, Xian-Jing, Wei, Lin-Xing, Fu, Min-Jie, Cheng, Zhou-Li, Yang, Zhen, Zhu, Gui-Qi, Wang, Xu-Dong, Zhang, Cheng, Zhang, Jin-Ye, Sun, Yi-Ping, Saiyin, Hexige, Zhang, Jin, Liu, Wei-Ren, Zhu, Wen-Wei, Guan, Kun-Liang, Xiong, Yue, Yang, Yong, Ye, Dan, Chen, Lei-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146892/
https://www.ncbi.nlm.nih.gov/pubmed/37115931
http://dx.doi.org/10.1126/sciadv.adg0654

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