Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells

Maturation of antibody responses entails somatic hypermutation (SHM), class-switch DNA recombination (CSR), plasma cell differentiation, and generation of memory B cells, and it is thought to require T cell help. We showed that B cell Toll-like receptor 4 (TLR4)–B cell receptor (BCR) (receptor for a...

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Detalles Bibliográficos
Autores principales: Rivera, Carlos E., Zhou, Yulai, Chupp, Daniel P., Yan, Hui, Fisher, Amanda D., Simon, Raphael, Zan, Hong, Xu, Zhenming, Casali, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146914/
https://www.ncbi.nlm.nih.gov/pubmed/37115935
http://dx.doi.org/10.1126/sciadv.ade8928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146914/
https://www.ncbi.nlm.nih.gov/pubmed/37115935
http://dx.doi.org/10.1126/sciadv.ade8928

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