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Mutated Flt3Lg Provides Reduced Flt3 Recycling Compared to Wild-Type Flt3Lg and Retains the Specificity of Flt3Lg-Based CAR T-Cell Targeting in AML Models

The cells of acute myeloid leukemia are defined by clonal growth and heterogenous immunophenotypes. Chimeric antigen receptors (CARs) commonly recognize molecular targets by single-chain antibody fragments (scFvs) specific to a tumor-associated antigen. However, ScFvs may form aggregates, thus stimu...

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Detalles Bibliográficos
Autores principales:	Maiorova, Varvara, Mollaev, Murad D., Vikhreva, Polina, Chudakov, Dmitriy M., Kibardin, Alexey, Maschan, Michael A., Larin, Sergey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146938/ https://www.ncbi.nlm.nih.gov/pubmed/37108788 http://dx.doi.org/10.3390/ijms24087626

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