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author Collatuzzo, Giulia
Negri, Eva
Pelucchi, Claudio
Bonzi, Rossella
Turati, Federica
Rabkin, Charles S.
Liao, Linda M.
Sinha, Rashmi
Palli, Domenico
Ferraroni, Monica
López-Carrillo, Lizbeth
Lunet, Nuno
Morais, Samantha
Albanes, Demetrius
Weinstein, Stephanie J.
Parisi, Dominick
Zaridze, David
Maximovitch, Dmitry
Dierssen-Sotos, Trinidad
Jiménez-Moleón, José Juan
Vioque, Jesus
Garcia de la Hera, Manoli
Curado, Maria Paula
Dias-Neto, Emmanuel
Hernández-Ramírez, Raúl Ulises
López-Cervantes, Malaquias
Ward, Mary H.
Tsugane, Shoichiro
Hidaka, Akihisa
Lagiou, Areti
Lagiou, Pagona
Zhang, Zuo-Feng
Trichopoulou, Antonia
Karakatsani, Anna
Camargo, Maria Constanza
La Vecchia, Carlo
Boffetta, Paolo
author_facet Collatuzzo, Giulia
Negri, Eva
Pelucchi, Claudio
Bonzi, Rossella
Turati, Federica
Rabkin, Charles S.
Liao, Linda M.
Sinha, Rashmi
Palli, Domenico
Ferraroni, Monica
López-Carrillo, Lizbeth
Lunet, Nuno
Morais, Samantha
Albanes, Demetrius
Weinstein, Stephanie J.
Parisi, Dominick
Zaridze, David
Maximovitch, Dmitry
Dierssen-Sotos, Trinidad
Jiménez-Moleón, José Juan
Vioque, Jesus
Garcia de la Hera, Manoli
Curado, Maria Paula
Dias-Neto, Emmanuel
Hernández-Ramírez, Raúl Ulises
López-Cervantes, Malaquias
Ward, Mary H.
Tsugane, Shoichiro
Hidaka, Akihisa
Lagiou, Areti
Lagiou, Pagona
Zhang, Zuo-Feng
Trichopoulou, Antonia
Karakatsani, Anna
Camargo, Maria Constanza
La Vecchia, Carlo
Boffetta, Paolo
author_sort Collatuzzo, Giulia
collection PubMed
description Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94–1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88–0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85–0.99) and 0.78 (95% CI = 0.73–0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91–1.02) for cardia, 1.03 (95% CI = 1.00–1.07) for non-cardia, 1.12 (95% CI = 1.07–1.19) for diffuse and 1.02 (95% CI = 0.97–1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association.
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spelling pubmed-101470102023-04-29 Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium Collatuzzo, Giulia Negri, Eva Pelucchi, Claudio Bonzi, Rossella Turati, Federica Rabkin, Charles S. Liao, Linda M. Sinha, Rashmi Palli, Domenico Ferraroni, Monica López-Carrillo, Lizbeth Lunet, Nuno Morais, Samantha Albanes, Demetrius Weinstein, Stephanie J. Parisi, Dominick Zaridze, David Maximovitch, Dmitry Dierssen-Sotos, Trinidad Jiménez-Moleón, José Juan Vioque, Jesus Garcia de la Hera, Manoli Curado, Maria Paula Dias-Neto, Emmanuel Hernández-Ramírez, Raúl Ulises López-Cervantes, Malaquias Ward, Mary H. Tsugane, Shoichiro Hidaka, Akihisa Lagiou, Areti Lagiou, Pagona Zhang, Zuo-Feng Trichopoulou, Antonia Karakatsani, Anna Camargo, Maria Constanza La Vecchia, Carlo Boffetta, Paolo Nutrients Article Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94–1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88–0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85–0.99) and 0.78 (95% CI = 0.73–0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91–1.02) for cardia, 1.03 (95% CI = 1.00–1.07) for non-cardia, 1.12 (95% CI = 1.07–1.19) for diffuse and 1.02 (95% CI = 0.97–1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association. MDPI 2023-04-13 /pmc/articles/PMC10147010/ /pubmed/37111097 http://dx.doi.org/10.3390/nu15081877 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Collatuzzo, Giulia
Negri, Eva
Pelucchi, Claudio
Bonzi, Rossella
Turati, Federica
Rabkin, Charles S.
Liao, Linda M.
Sinha, Rashmi
Palli, Domenico
Ferraroni, Monica
López-Carrillo, Lizbeth
Lunet, Nuno
Morais, Samantha
Albanes, Demetrius
Weinstein, Stephanie J.
Parisi, Dominick
Zaridze, David
Maximovitch, Dmitry
Dierssen-Sotos, Trinidad
Jiménez-Moleón, José Juan
Vioque, Jesus
Garcia de la Hera, Manoli
Curado, Maria Paula
Dias-Neto, Emmanuel
Hernández-Ramírez, Raúl Ulises
López-Cervantes, Malaquias
Ward, Mary H.
Tsugane, Shoichiro
Hidaka, Akihisa
Lagiou, Areti
Lagiou, Pagona
Zhang, Zuo-Feng
Trichopoulou, Antonia
Karakatsani, Anna
Camargo, Maria Constanza
La Vecchia, Carlo
Boffetta, Paolo
Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium
title Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium
title_full Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium
title_fullStr Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium
title_full_unstemmed Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium
title_short Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium
title_sort yoghurt intake and gastric cancer: a pooled analysis of 16 studies of the stop consortium
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147010/
https://www.ncbi.nlm.nih.gov/pubmed/37111097
http://dx.doi.org/10.3390/nu15081877
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