Cargando…
Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium
Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yogh...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147010/ https://www.ncbi.nlm.nih.gov/pubmed/37111097 http://dx.doi.org/10.3390/nu15081877 |
_version_ | 1785034714005897216 |
---|---|
author | Collatuzzo, Giulia Negri, Eva Pelucchi, Claudio Bonzi, Rossella Turati, Federica Rabkin, Charles S. Liao, Linda M. Sinha, Rashmi Palli, Domenico Ferraroni, Monica López-Carrillo, Lizbeth Lunet, Nuno Morais, Samantha Albanes, Demetrius Weinstein, Stephanie J. Parisi, Dominick Zaridze, David Maximovitch, Dmitry Dierssen-Sotos, Trinidad Jiménez-Moleón, José Juan Vioque, Jesus Garcia de la Hera, Manoli Curado, Maria Paula Dias-Neto, Emmanuel Hernández-Ramírez, Raúl Ulises López-Cervantes, Malaquias Ward, Mary H. Tsugane, Shoichiro Hidaka, Akihisa Lagiou, Areti Lagiou, Pagona Zhang, Zuo-Feng Trichopoulou, Antonia Karakatsani, Anna Camargo, Maria Constanza La Vecchia, Carlo Boffetta, Paolo |
author_facet | Collatuzzo, Giulia Negri, Eva Pelucchi, Claudio Bonzi, Rossella Turati, Federica Rabkin, Charles S. Liao, Linda M. Sinha, Rashmi Palli, Domenico Ferraroni, Monica López-Carrillo, Lizbeth Lunet, Nuno Morais, Samantha Albanes, Demetrius Weinstein, Stephanie J. Parisi, Dominick Zaridze, David Maximovitch, Dmitry Dierssen-Sotos, Trinidad Jiménez-Moleón, José Juan Vioque, Jesus Garcia de la Hera, Manoli Curado, Maria Paula Dias-Neto, Emmanuel Hernández-Ramírez, Raúl Ulises López-Cervantes, Malaquias Ward, Mary H. Tsugane, Shoichiro Hidaka, Akihisa Lagiou, Areti Lagiou, Pagona Zhang, Zuo-Feng Trichopoulou, Antonia Karakatsani, Anna Camargo, Maria Constanza La Vecchia, Carlo Boffetta, Paolo |
author_sort | Collatuzzo, Giulia |
collection | PubMed |
description | Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94–1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88–0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85–0.99) and 0.78 (95% CI = 0.73–0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91–1.02) for cardia, 1.03 (95% CI = 1.00–1.07) for non-cardia, 1.12 (95% CI = 1.07–1.19) for diffuse and 1.02 (95% CI = 0.97–1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association. |
format | Online Article Text |
id | pubmed-10147010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101470102023-04-29 Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium Collatuzzo, Giulia Negri, Eva Pelucchi, Claudio Bonzi, Rossella Turati, Federica Rabkin, Charles S. Liao, Linda M. Sinha, Rashmi Palli, Domenico Ferraroni, Monica López-Carrillo, Lizbeth Lunet, Nuno Morais, Samantha Albanes, Demetrius Weinstein, Stephanie J. Parisi, Dominick Zaridze, David Maximovitch, Dmitry Dierssen-Sotos, Trinidad Jiménez-Moleón, José Juan Vioque, Jesus Garcia de la Hera, Manoli Curado, Maria Paula Dias-Neto, Emmanuel Hernández-Ramírez, Raúl Ulises López-Cervantes, Malaquias Ward, Mary H. Tsugane, Shoichiro Hidaka, Akihisa Lagiou, Areti Lagiou, Pagona Zhang, Zuo-Feng Trichopoulou, Antonia Karakatsani, Anna Camargo, Maria Constanza La Vecchia, Carlo Boffetta, Paolo Nutrients Article Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94–1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88–0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85–0.99) and 0.78 (95% CI = 0.73–0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91–1.02) for cardia, 1.03 (95% CI = 1.00–1.07) for non-cardia, 1.12 (95% CI = 1.07–1.19) for diffuse and 1.02 (95% CI = 0.97–1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association. MDPI 2023-04-13 /pmc/articles/PMC10147010/ /pubmed/37111097 http://dx.doi.org/10.3390/nu15081877 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Collatuzzo, Giulia Negri, Eva Pelucchi, Claudio Bonzi, Rossella Turati, Federica Rabkin, Charles S. Liao, Linda M. Sinha, Rashmi Palli, Domenico Ferraroni, Monica López-Carrillo, Lizbeth Lunet, Nuno Morais, Samantha Albanes, Demetrius Weinstein, Stephanie J. Parisi, Dominick Zaridze, David Maximovitch, Dmitry Dierssen-Sotos, Trinidad Jiménez-Moleón, José Juan Vioque, Jesus Garcia de la Hera, Manoli Curado, Maria Paula Dias-Neto, Emmanuel Hernández-Ramírez, Raúl Ulises López-Cervantes, Malaquias Ward, Mary H. Tsugane, Shoichiro Hidaka, Akihisa Lagiou, Areti Lagiou, Pagona Zhang, Zuo-Feng Trichopoulou, Antonia Karakatsani, Anna Camargo, Maria Constanza La Vecchia, Carlo Boffetta, Paolo Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium |
title | Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium |
title_full | Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium |
title_fullStr | Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium |
title_full_unstemmed | Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium |
title_short | Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium |
title_sort | yoghurt intake and gastric cancer: a pooled analysis of 16 studies of the stop consortium |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147010/ https://www.ncbi.nlm.nih.gov/pubmed/37111097 http://dx.doi.org/10.3390/nu15081877 |
work_keys_str_mv | AT collatuzzogiulia yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT negrieva yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT pelucchiclaudio yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT bonzirossella yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT turatifederica yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT rabkincharless yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT liaolindam yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT sinharashmi yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT pallidomenico yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT ferraronimonica yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT lopezcarrillolizbeth yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT lunetnuno yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT moraissamantha yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT albanesdemetrius yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT weinsteinstephaniej yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT parisidominick yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT zaridzedavid yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT maximovitchdmitry yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT dierssensotostrinidad yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT jimenezmoleonjosejuan yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT vioquejesus yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT garciadelaheramanoli yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT curadomariapaula yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT diasnetoemmanuel yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT hernandezramirezraululises yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT lopezcervantesmalaquias yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT wardmaryh yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT tsuganeshoichiro yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT hidakaakihisa yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT lagiouareti yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT lagioupagona yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT zhangzuofeng yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT trichopoulouantonia yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT karakatsanianna yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT camargomariaconstanza yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT lavecchiacarlo yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium AT boffettapaolo yoghurtintakeandgastriccancerapooledanalysisof16studiesofthestopconsortium |