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Renal Amyloidosis (AL Kappa Type) With an Uncommon Presentation: A Case Report

Amyloidosis is a disease associated with deposits of amyloid fibrils that aggregate in various tissues leading to progressive organ failure and often multi-systemic involvement. It may be classified as localized or systemic, acquired or hereditary. Renal presentation is variable but can include neph...

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Autores principales: Botero, Stephanie A, Bass, Michelle, Botero Suarez, Carlos S, Kar, Pran, Abreu, Elpidio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147497/
https://www.ncbi.nlm.nih.gov/pubmed/37123730
http://dx.doi.org/10.7759/cureus.36867
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author Botero, Stephanie A
Bass, Michelle
Botero Suarez, Carlos S
Kar, Pran
Abreu, Elpidio
author_facet Botero, Stephanie A
Bass, Michelle
Botero Suarez, Carlos S
Kar, Pran
Abreu, Elpidio
author_sort Botero, Stephanie A
collection PubMed
description Amyloidosis is a disease associated with deposits of amyloid fibrils that aggregate in various tissues leading to progressive organ failure and often multi-systemic involvement. It may be classified as localized or systemic, acquired or hereditary. Renal presentation is variable but can include nephrotic syndrome, acute renal failure, tubular dysfunction, or just varying degrees of proteinuria. Although most cases of renal amyloidosis are due to acquired causes, in rare instances, the cause can be gene mutations leading to hereditary amyloidosis. We present the case of a 77-year-old Caucasian man diagnosed with renal biopsy-proven AL (kappa) type amyloidosis with isolated renal involvement who had a significant family history of renal biopsy-proven amyloidosis.
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spelling pubmed-101474972023-04-29 Renal Amyloidosis (AL Kappa Type) With an Uncommon Presentation: A Case Report Botero, Stephanie A Bass, Michelle Botero Suarez, Carlos S Kar, Pran Abreu, Elpidio Cureus Internal Medicine Amyloidosis is a disease associated with deposits of amyloid fibrils that aggregate in various tissues leading to progressive organ failure and often multi-systemic involvement. It may be classified as localized or systemic, acquired or hereditary. Renal presentation is variable but can include nephrotic syndrome, acute renal failure, tubular dysfunction, or just varying degrees of proteinuria. Although most cases of renal amyloidosis are due to acquired causes, in rare instances, the cause can be gene mutations leading to hereditary amyloidosis. We present the case of a 77-year-old Caucasian man diagnosed with renal biopsy-proven AL (kappa) type amyloidosis with isolated renal involvement who had a significant family history of renal biopsy-proven amyloidosis. Cureus 2023-03-29 /pmc/articles/PMC10147497/ /pubmed/37123730 http://dx.doi.org/10.7759/cureus.36867 Text en Copyright © 2023, Botero et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Botero, Stephanie A
Bass, Michelle
Botero Suarez, Carlos S
Kar, Pran
Abreu, Elpidio
Renal Amyloidosis (AL Kappa Type) With an Uncommon Presentation: A Case Report
title Renal Amyloidosis (AL Kappa Type) With an Uncommon Presentation: A Case Report
title_full Renal Amyloidosis (AL Kappa Type) With an Uncommon Presentation: A Case Report
title_fullStr Renal Amyloidosis (AL Kappa Type) With an Uncommon Presentation: A Case Report
title_full_unstemmed Renal Amyloidosis (AL Kappa Type) With an Uncommon Presentation: A Case Report
title_short Renal Amyloidosis (AL Kappa Type) With an Uncommon Presentation: A Case Report
title_sort renal amyloidosis (al kappa type) with an uncommon presentation: a case report
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147497/
https://www.ncbi.nlm.nih.gov/pubmed/37123730
http://dx.doi.org/10.7759/cureus.36867
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