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Predictors of Mortality Among Post-COVID-19 Discharged Patients in Northern India: A Case-Control Study
Introduction The post-discharge all-cause mortality of COVID-19 disease is known, but predictors for the same have not been studied as much. The objective of this study was to develop an understanding of predictors of mortality to guide in prioritizing patient care and preventive approaches. Methods...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147556/ https://www.ncbi.nlm.nih.gov/pubmed/37128527 http://dx.doi.org/10.7759/cureus.36883 |
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author | Kumar, Arjun Jatteppanvar, Basavaraj Panda, Prasan K Dhangar, Pathik Bahurupi, Yogesh A |
author_facet | Kumar, Arjun Jatteppanvar, Basavaraj Panda, Prasan K Dhangar, Pathik Bahurupi, Yogesh A |
author_sort | Kumar, Arjun |
collection | PubMed |
description | Introduction The post-discharge all-cause mortality of COVID-19 disease is known, but predictors for the same have not been studied as much. The objective of this study was to develop an understanding of predictors of mortality to guide in prioritizing patient care and preventive approaches. Methods This current research is a single-center unmatched case-control study conducted at a tertiary care center in northern India, between April and September 2022. The data were extracted retrospectively from the hospital's electronic medical records of patients with the assistance of trained physicians using a standardized data extraction sheet. Results A total of 184 patients were enrolled and were segregated into two groups, cases and control, with 92 in each. The mean age of patients was 49.3 ± 17.53 years. The mortality group had a higher mean age (53.24 ± 18.53 yrs) as compared to the control group (45.37 ± 15.58 yrs, p=0.002). Bivariate analysis revealed a significant difference in the two groups with respect to O(2) saturation at the time of admission (case - 91.12 ± 12.49 %, control - 95.46 ± 5.01 %, p=0.003); maximum O(2) flow rate (L/min) (case - 11.01 ± 22.2, control - 6.41 ± 13.31, p=0.04); ICU need (p=0.005), cancer (p=0.001), O(2) requirement at discharge (p=0.001) and acute kidney injury (AKI; p=0.007). On multiple regression analysis, cancer (adjusted odds ratio (aOR) - 2.469; 95% CI 1.183-5.150, p=0.016), ICU admission (aOR - 2.446; 95% CI 1.212-4.938, p=0.013), oxygen at discharge (aOR - 2.340; 95% CI 0.971-5.640, p=0.0586) and AKI (aOR - 5.6; 95% CI 2.351- 13.370, p=0.00) only found to be significant. Conclusion Among the patients released from the hospital post-COVID-19 treatment, the following aspects oxygen requirement (2.3 times), malignancy (2.4 times), ICU admission (2.4 times), and AKI (5.6 times) are risk factors of mortality. The presence of these variables would warrant a close follow-up for these patients in order to decrease post-COVID mortality. |
format | Online Article Text |
id | pubmed-10147556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-101475562023-04-30 Predictors of Mortality Among Post-COVID-19 Discharged Patients in Northern India: A Case-Control Study Kumar, Arjun Jatteppanvar, Basavaraj Panda, Prasan K Dhangar, Pathik Bahurupi, Yogesh A Cureus Family/General Practice Introduction The post-discharge all-cause mortality of COVID-19 disease is known, but predictors for the same have not been studied as much. The objective of this study was to develop an understanding of predictors of mortality to guide in prioritizing patient care and preventive approaches. Methods This current research is a single-center unmatched case-control study conducted at a tertiary care center in northern India, between April and September 2022. The data were extracted retrospectively from the hospital's electronic medical records of patients with the assistance of trained physicians using a standardized data extraction sheet. Results A total of 184 patients were enrolled and were segregated into two groups, cases and control, with 92 in each. The mean age of patients was 49.3 ± 17.53 years. The mortality group had a higher mean age (53.24 ± 18.53 yrs) as compared to the control group (45.37 ± 15.58 yrs, p=0.002). Bivariate analysis revealed a significant difference in the two groups with respect to O(2) saturation at the time of admission (case - 91.12 ± 12.49 %, control - 95.46 ± 5.01 %, p=0.003); maximum O(2) flow rate (L/min) (case - 11.01 ± 22.2, control - 6.41 ± 13.31, p=0.04); ICU need (p=0.005), cancer (p=0.001), O(2) requirement at discharge (p=0.001) and acute kidney injury (AKI; p=0.007). On multiple regression analysis, cancer (adjusted odds ratio (aOR) - 2.469; 95% CI 1.183-5.150, p=0.016), ICU admission (aOR - 2.446; 95% CI 1.212-4.938, p=0.013), oxygen at discharge (aOR - 2.340; 95% CI 0.971-5.640, p=0.0586) and AKI (aOR - 5.6; 95% CI 2.351- 13.370, p=0.00) only found to be significant. Conclusion Among the patients released from the hospital post-COVID-19 treatment, the following aspects oxygen requirement (2.3 times), malignancy (2.4 times), ICU admission (2.4 times), and AKI (5.6 times) are risk factors of mortality. The presence of these variables would warrant a close follow-up for these patients in order to decrease post-COVID mortality. Cureus 2023-03-29 /pmc/articles/PMC10147556/ /pubmed/37128527 http://dx.doi.org/10.7759/cureus.36883 Text en Copyright © 2023, Kumar et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Family/General Practice Kumar, Arjun Jatteppanvar, Basavaraj Panda, Prasan K Dhangar, Pathik Bahurupi, Yogesh A Predictors of Mortality Among Post-COVID-19 Discharged Patients in Northern India: A Case-Control Study |
title | Predictors of Mortality Among Post-COVID-19 Discharged Patients in Northern India: A Case-Control Study |
title_full | Predictors of Mortality Among Post-COVID-19 Discharged Patients in Northern India: A Case-Control Study |
title_fullStr | Predictors of Mortality Among Post-COVID-19 Discharged Patients in Northern India: A Case-Control Study |
title_full_unstemmed | Predictors of Mortality Among Post-COVID-19 Discharged Patients in Northern India: A Case-Control Study |
title_short | Predictors of Mortality Among Post-COVID-19 Discharged Patients in Northern India: A Case-Control Study |
title_sort | predictors of mortality among post-covid-19 discharged patients in northern india: a case-control study |
topic | Family/General Practice |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147556/ https://www.ncbi.nlm.nih.gov/pubmed/37128527 http://dx.doi.org/10.7759/cureus.36883 |
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