An aptamer-based depot system for sustained release of small molecule therapeutics

Delivery of hydrophilic small molecule therapeutics by traditional drug delivery systems is challenging. Herein, we have used the specific interaction between DNA aptamers and drugs to create simple and effective drug depot systems. The specific binding of a phosphorothioate-modified aptamer to drug...

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Detalles Bibliográficos
Autores principales: Wang, Dali, Li, Yang, Deng, Xiaoran, Torre, Matthew, Zhang, Zipei, Li, Xiyu, Zhang, Wei, Cullion, Kathleen, Kohane, Daniel S., Weldon, Christopher B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147605/
https://www.ncbi.nlm.nih.gov/pubmed/37117194
http://dx.doi.org/10.1038/s41467-023-37002-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147605/
https://www.ncbi.nlm.nih.gov/pubmed/37117194
http://dx.doi.org/10.1038/s41467-023-37002-0

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