MSI2 promotes translation of multiple IRES-containing oncogenes and virus to induce self-renewal of tumor initiating stem-like cells

RNA-binding protein Musashi 2 (MSI2) is elevated in several cancers and is linked to poor prognosis. Here, we tested if MSI2 promotes MYC and viral mRNA translation to induce self-renewal via an internal ribosome entry sequence (IRES). We performed RIP-seq using anti-MSI2 antibody in tumor-initiatin...

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Detalles Bibliográficos
Autores principales: Yeh, Da-Wei, Zhao, Xuyao, Siddique, Hifzur R., Zheng, Mengmei, Choi, Hye Yeon, Machida, Tatsuya, Narayanan, Padmini, Kou, Yi, Punj, Vasu, Tahara, Stanley M., Feldman, Douglas E., Chen, Lin, Machida, Keigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147607/
https://www.ncbi.nlm.nih.gov/pubmed/37117191
http://dx.doi.org/10.1038/s41420-023-01427-9

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