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The Newfoundland and Labrador mosaic founder population descends from an Irish and British diaspora from 300 years ago
The founder population of Newfoundland and Labrador (NL) is a unique genetic resource, in part due to its geographic and cultural isolation, where historical records describe a migration of European settlers, primarily from Ireland and England, to NL in the 18th and 19th centuries. Whilst its histor...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147672/ https://www.ncbi.nlm.nih.gov/pubmed/37117635 http://dx.doi.org/10.1038/s42003-023-04844-9 |
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author | Gilbert, Edmund Zurel, Heather MacMillan, Margaret E. Demiriz, Sedat Mirhendi, Sadra Merrigan, Michael O’Reilly, Seamus Molloy, Anne M. Brody, Lawrence C. Bodmer, Walter Leach, Richard A. Scott, Roderick E. M. Mugford, Gerald Randhawa, Ranjit Stephens, J. Claiborne Symington, Alison L. Cavalleri, Gianpiero L. Phillips, Michael S. |
author_facet | Gilbert, Edmund Zurel, Heather MacMillan, Margaret E. Demiriz, Sedat Mirhendi, Sadra Merrigan, Michael O’Reilly, Seamus Molloy, Anne M. Brody, Lawrence C. Bodmer, Walter Leach, Richard A. Scott, Roderick E. M. Mugford, Gerald Randhawa, Ranjit Stephens, J. Claiborne Symington, Alison L. Cavalleri, Gianpiero L. Phillips, Michael S. |
author_sort | Gilbert, Edmund |
collection | PubMed |
description | The founder population of Newfoundland and Labrador (NL) is a unique genetic resource, in part due to its geographic and cultural isolation, where historical records describe a migration of European settlers, primarily from Ireland and England, to NL in the 18th and 19th centuries. Whilst its historical isolation, and increased prevalence of certain monogenic disorders are well appreciated, details of the fine-scale genetic structure and ancestry of the population are lacking. Understanding the genetic origins and background of functional, disease causing, genetic variants would aid genetic mapping efforts in the Province. Here, we leverage dense genome-wide SNP data on 1,807 NL individuals to reveal fine-scale genetic structure in NL that is clustered around coastal communities and correlated with Christian denomination. We show that the majority of NL European ancestry can be traced back to the south-east and south-west of Ireland and England, respectively. We date a substantial population size bottleneck approximately 10-15 generations ago in NL, associated with increased haplotype sharing and autozygosity. Our results reveal insights into the population history of NL and demonstrate evidence of a population conducive to further genetic studies and biomarker discovery. |
format | Online Article Text |
id | pubmed-10147672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-101476722023-04-30 The Newfoundland and Labrador mosaic founder population descends from an Irish and British diaspora from 300 years ago Gilbert, Edmund Zurel, Heather MacMillan, Margaret E. Demiriz, Sedat Mirhendi, Sadra Merrigan, Michael O’Reilly, Seamus Molloy, Anne M. Brody, Lawrence C. Bodmer, Walter Leach, Richard A. Scott, Roderick E. M. Mugford, Gerald Randhawa, Ranjit Stephens, J. Claiborne Symington, Alison L. Cavalleri, Gianpiero L. Phillips, Michael S. Commun Biol Article The founder population of Newfoundland and Labrador (NL) is a unique genetic resource, in part due to its geographic and cultural isolation, where historical records describe a migration of European settlers, primarily from Ireland and England, to NL in the 18th and 19th centuries. Whilst its historical isolation, and increased prevalence of certain monogenic disorders are well appreciated, details of the fine-scale genetic structure and ancestry of the population are lacking. Understanding the genetic origins and background of functional, disease causing, genetic variants would aid genetic mapping efforts in the Province. Here, we leverage dense genome-wide SNP data on 1,807 NL individuals to reveal fine-scale genetic structure in NL that is clustered around coastal communities and correlated with Christian denomination. We show that the majority of NL European ancestry can be traced back to the south-east and south-west of Ireland and England, respectively. We date a substantial population size bottleneck approximately 10-15 generations ago in NL, associated with increased haplotype sharing and autozygosity. Our results reveal insights into the population history of NL and demonstrate evidence of a population conducive to further genetic studies and biomarker discovery. Nature Publishing Group UK 2023-04-28 /pmc/articles/PMC10147672/ /pubmed/37117635 http://dx.doi.org/10.1038/s42003-023-04844-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Gilbert, Edmund Zurel, Heather MacMillan, Margaret E. Demiriz, Sedat Mirhendi, Sadra Merrigan, Michael O’Reilly, Seamus Molloy, Anne M. Brody, Lawrence C. Bodmer, Walter Leach, Richard A. Scott, Roderick E. M. Mugford, Gerald Randhawa, Ranjit Stephens, J. Claiborne Symington, Alison L. Cavalleri, Gianpiero L. Phillips, Michael S. The Newfoundland and Labrador mosaic founder population descends from an Irish and British diaspora from 300 years ago |
title | The Newfoundland and Labrador mosaic founder population descends from an Irish and British diaspora from 300 years ago |
title_full | The Newfoundland and Labrador mosaic founder population descends from an Irish and British diaspora from 300 years ago |
title_fullStr | The Newfoundland and Labrador mosaic founder population descends from an Irish and British diaspora from 300 years ago |
title_full_unstemmed | The Newfoundland and Labrador mosaic founder population descends from an Irish and British diaspora from 300 years ago |
title_short | The Newfoundland and Labrador mosaic founder population descends from an Irish and British diaspora from 300 years ago |
title_sort | newfoundland and labrador mosaic founder population descends from an irish and british diaspora from 300 years ago |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147672/ https://www.ncbi.nlm.nih.gov/pubmed/37117635 http://dx.doi.org/10.1038/s42003-023-04844-9 |
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