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DNA double-strand break-free CRISPR interference delays Huntington’s disease progression in mice

Huntington’s disease (HD) is caused by a CAG repeat expansion in the huntingtin (HTT) gene. CRISPR-Cas9 nuclease causes double-strand breaks (DSBs) in the targeted DNA that induces toxicity, whereas CRISPR interference (CRISPRi) using dead Cas9 (dCas9) suppresses the target gene expression without D...

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Detalles Bibliográficos
Autores principales:	Seo, Jung Hwa, Shin, Jeong Hong, Lee, Junwon, Kim, Daesik, Hwang, Hye-Yeon, Nam, Bae-Geun, Lee, Jinu, Kim, Hyongbum Henry, Cho, Sung-Rae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147674/ https://www.ncbi.nlm.nih.gov/pubmed/37117485 http://dx.doi.org/10.1038/s42003-023-04829-8

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