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The reproducibility of MTV and TLG of soft tissue tumors calculated by FDG-PET: Comparison between the lower limit by the fixed value SUV 2.5 and that value by 30% of SUVmax

PURPOSE: We evaluated the reproducibility calculating volume-based FDG-PET/CT parameters, i.e., metabolic tumor volume (MTV) and total lesion glycolysis (TLG), in soft tissue tumors. MATERIALS AND METHODS: Fifty-three cases with soft tissue tumors were analyzed retrospectively. The conditions determ...

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Autores principales: Iwasa, Hitomi, Nagamachi, Shigeki, Nakayama, Shizuhide, Yamamoto, Takuaki, Yoshimitsu, Kengo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147792/
https://www.ncbi.nlm.nih.gov/pubmed/36637680
http://dx.doi.org/10.1007/s11604-022-01378-8
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author Iwasa, Hitomi
Nagamachi, Shigeki
Nakayama, Shizuhide
Yamamoto, Takuaki
Yoshimitsu, Kengo
author_facet Iwasa, Hitomi
Nagamachi, Shigeki
Nakayama, Shizuhide
Yamamoto, Takuaki
Yoshimitsu, Kengo
author_sort Iwasa, Hitomi
collection PubMed
description PURPOSE: We evaluated the reproducibility calculating volume-based FDG-PET/CT parameters, i.e., metabolic tumor volume (MTV) and total lesion glycolysis (TLG), in soft tissue tumors. MATERIALS AND METHODS: Fifty-three cases with soft tissue tumors were analyzed retrospectively. The conditions determining the lower limit of MTV were fixed value SUV 2.5 or 30% of SUVmax. To investigate the agreement of the measurements by two radiologists, %difference, the correlation coefficients and Bland–Altman plot were analyzed. We compared these parameters in both intra- and inter-operator for evaluating the agreement in the measurements. RESULTS: The values of % difference were excellent, 0.2–3.5%, in the intra-operator in all calculated volume-based parameters. In both inter- and intra-operator analysis, the values of % differences were lower in the parameters calculated by SUV 2.5 fixed value as a lower threshold compared with those calculated by 30% of SUVmax as a lower threshold. The correlation coefficient in MTV30% for inter-operator were 0.84 or 0.87, those were lower than values by the intra-operator evaluation. Nevertheless, the correlation coefficients were higher than 0.84 in every parameter. Particularly, correlation coefficient in the parameters calculated by SUV 2.5 fixed value was better than those calculated by 30% of SUVmax. The Bland–Altman plot analysis showed good agreement for all parameters, particularly in the intra-operator examinations. However, in the inter-operator study, some variances were noted in every condition. CONCLUSION: In conclusion, the reproducibility of measuring volume-based FDG-PET/CT parameters of soft tissue tumors was good, particularly, in the measurement by fixed lower limit value SUV 2.5 in the intra-operator.
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spelling pubmed-101477922023-04-30 The reproducibility of MTV and TLG of soft tissue tumors calculated by FDG-PET: Comparison between the lower limit by the fixed value SUV 2.5 and that value by 30% of SUVmax Iwasa, Hitomi Nagamachi, Shigeki Nakayama, Shizuhide Yamamoto, Takuaki Yoshimitsu, Kengo Jpn J Radiol Original Article PURPOSE: We evaluated the reproducibility calculating volume-based FDG-PET/CT parameters, i.e., metabolic tumor volume (MTV) and total lesion glycolysis (TLG), in soft tissue tumors. MATERIALS AND METHODS: Fifty-three cases with soft tissue tumors were analyzed retrospectively. The conditions determining the lower limit of MTV were fixed value SUV 2.5 or 30% of SUVmax. To investigate the agreement of the measurements by two radiologists, %difference, the correlation coefficients and Bland–Altman plot were analyzed. We compared these parameters in both intra- and inter-operator for evaluating the agreement in the measurements. RESULTS: The values of % difference were excellent, 0.2–3.5%, in the intra-operator in all calculated volume-based parameters. In both inter- and intra-operator analysis, the values of % differences were lower in the parameters calculated by SUV 2.5 fixed value as a lower threshold compared with those calculated by 30% of SUVmax as a lower threshold. The correlation coefficient in MTV30% for inter-operator were 0.84 or 0.87, those were lower than values by the intra-operator evaluation. Nevertheless, the correlation coefficients were higher than 0.84 in every parameter. Particularly, correlation coefficient in the parameters calculated by SUV 2.5 fixed value was better than those calculated by 30% of SUVmax. The Bland–Altman plot analysis showed good agreement for all parameters, particularly in the intra-operator examinations. However, in the inter-operator study, some variances were noted in every condition. CONCLUSION: In conclusion, the reproducibility of measuring volume-based FDG-PET/CT parameters of soft tissue tumors was good, particularly, in the measurement by fixed lower limit value SUV 2.5 in the intra-operator. Springer Nature Singapore 2023-01-13 2023 /pmc/articles/PMC10147792/ /pubmed/36637680 http://dx.doi.org/10.1007/s11604-022-01378-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Iwasa, Hitomi
Nagamachi, Shigeki
Nakayama, Shizuhide
Yamamoto, Takuaki
Yoshimitsu, Kengo
The reproducibility of MTV and TLG of soft tissue tumors calculated by FDG-PET: Comparison between the lower limit by the fixed value SUV 2.5 and that value by 30% of SUVmax
title The reproducibility of MTV and TLG of soft tissue tumors calculated by FDG-PET: Comparison between the lower limit by the fixed value SUV 2.5 and that value by 30% of SUVmax
title_full The reproducibility of MTV and TLG of soft tissue tumors calculated by FDG-PET: Comparison between the lower limit by the fixed value SUV 2.5 and that value by 30% of SUVmax
title_fullStr The reproducibility of MTV and TLG of soft tissue tumors calculated by FDG-PET: Comparison between the lower limit by the fixed value SUV 2.5 and that value by 30% of SUVmax
title_full_unstemmed The reproducibility of MTV and TLG of soft tissue tumors calculated by FDG-PET: Comparison between the lower limit by the fixed value SUV 2.5 and that value by 30% of SUVmax
title_short The reproducibility of MTV and TLG of soft tissue tumors calculated by FDG-PET: Comparison between the lower limit by the fixed value SUV 2.5 and that value by 30% of SUVmax
title_sort reproducibility of mtv and tlg of soft tissue tumors calculated by fdg-pet: comparison between the lower limit by the fixed value suv 2.5 and that value by 30% of suvmax
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147792/
https://www.ncbi.nlm.nih.gov/pubmed/36637680
http://dx.doi.org/10.1007/s11604-022-01378-8
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