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Microstructural, biocompatibility and mechanical investigation of MgHAp and AgHAp: Comparative report

ABSTRACT: It is imperative to investigate the effect of addition of different size metallic ions in HAp and study the changes in biocompatibility and mechanical properties. Silver and magnesium ions are two vital ions needed in our body. Silver ions are known to inhibit the microbes, while magnesium...

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Autores principales: Mahanty, Anuradha, Shikha, Deep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147813/
https://www.ncbi.nlm.nih.gov/pubmed/37117909
http://dx.doi.org/10.1007/s10856-023-06725-3
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author Mahanty, Anuradha
Shikha, Deep
author_facet Mahanty, Anuradha
Shikha, Deep
author_sort Mahanty, Anuradha
collection PubMed
description ABSTRACT: It is imperative to investigate the effect of addition of different size metallic ions in HAp and study the changes in biocompatibility and mechanical properties. Silver and magnesium ions are two vital ions needed in our body. Silver ions are known to inhibit the microbes, while magnesium ions are known to increase the mechanical properties. The present study reports the comparative properties of MgHAp and AgHAp synthesised by sol-gel wet chemical method. Changes in the morphology, phase analysis, corrosion resistance, dielectric properties, hardness and the thrombus behaviour of HAp doped Ag and Mg ions has been investigated. In this work, we have presented a comparative study of both the metal doped ionsto find which of the ions and which weight percent of the ions can be best suited to be incorporated into the HAp matrix for hard tissue implants. All wt% AgHAp showed the better corrosion resistance than all the MgHAp samples. However, MgHAp showed higher value of hardness in comparison to AgHAp samples. The mechanical strength was found to increase with the increase in Mg wt% in MgHAp but for AgHAp the hardness value decreased with increase in the concentration. The impedance and dielectric loss decreased with increasing frequency for both the samples. Both the ion doped hydroxyapatite showed moderate clotting behaviour as compared to pure HAp. But 2 wt% MgHAp and 4 wt% AgHAp showed better thrombogenic behaviour. GRAPHICAL ABSTRACT: [Figure: see text]
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spelling pubmed-101478132023-04-30 Microstructural, biocompatibility and mechanical investigation of MgHAp and AgHAp: Comparative report Mahanty, Anuradha Shikha, Deep J Mater Sci Mater Med Biomaterials Synthesis and Characterization ABSTRACT: It is imperative to investigate the effect of addition of different size metallic ions in HAp and study the changes in biocompatibility and mechanical properties. Silver and magnesium ions are two vital ions needed in our body. Silver ions are known to inhibit the microbes, while magnesium ions are known to increase the mechanical properties. The present study reports the comparative properties of MgHAp and AgHAp synthesised by sol-gel wet chemical method. Changes in the morphology, phase analysis, corrosion resistance, dielectric properties, hardness and the thrombus behaviour of HAp doped Ag and Mg ions has been investigated. In this work, we have presented a comparative study of both the metal doped ionsto find which of the ions and which weight percent of the ions can be best suited to be incorporated into the HAp matrix for hard tissue implants. All wt% AgHAp showed the better corrosion resistance than all the MgHAp samples. However, MgHAp showed higher value of hardness in comparison to AgHAp samples. The mechanical strength was found to increase with the increase in Mg wt% in MgHAp but for AgHAp the hardness value decreased with increase in the concentration. The impedance and dielectric loss decreased with increasing frequency for both the samples. Both the ion doped hydroxyapatite showed moderate clotting behaviour as compared to pure HAp. But 2 wt% MgHAp and 4 wt% AgHAp showed better thrombogenic behaviour. GRAPHICAL ABSTRACT: [Figure: see text] Springer US 2023-04-28 2023 /pmc/articles/PMC10147813/ /pubmed/37117909 http://dx.doi.org/10.1007/s10856-023-06725-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biomaterials Synthesis and Characterization
Mahanty, Anuradha
Shikha, Deep
Microstructural, biocompatibility and mechanical investigation of MgHAp and AgHAp: Comparative report
title Microstructural, biocompatibility and mechanical investigation of MgHAp and AgHAp: Comparative report
title_full Microstructural, biocompatibility and mechanical investigation of MgHAp and AgHAp: Comparative report
title_fullStr Microstructural, biocompatibility and mechanical investigation of MgHAp and AgHAp: Comparative report
title_full_unstemmed Microstructural, biocompatibility and mechanical investigation of MgHAp and AgHAp: Comparative report
title_short Microstructural, biocompatibility and mechanical investigation of MgHAp and AgHAp: Comparative report
title_sort microstructural, biocompatibility and mechanical investigation of mghap and aghap: comparative report
topic Biomaterials Synthesis and Characterization
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147813/
https://www.ncbi.nlm.nih.gov/pubmed/37117909
http://dx.doi.org/10.1007/s10856-023-06725-3
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