Generation of functional thymic organoids from human pluripotent stem cells

The thymus is critical for the establishment of a functional and self-tolerant adaptive immune system but involutes with age, resulting in reduced naive T cell output. Generation of a functional human thymus from human pluripotent stem cells (hPSCs) is an attractive regenerative strategy. Direct dif...

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Detalles Bibliográficos
Autores principales: Ramos, Stephan A., Armitage, Lucas H., Morton, John J., Alzofon, Nathaniel, Handler, Diana, Kelly, Geoffrey, Homann, Dirk, Jimeno, Antonio, Russ, Holger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147832/
https://www.ncbi.nlm.nih.gov/pubmed/36963390
http://dx.doi.org/10.1016/j.stemcr.2023.02.013

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