Pain-causing stinging nettle toxins target TMEM233 to modulate Na(V)1.7 function

Voltage-gated sodium (Na(V)) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the voltage-sensing domains, or residues forming part of the pore domain. Excelsatoxin A...

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Detalles Bibliográficos
Autores principales: Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N., Zhao, Jing, Stehbens, Samantha J., Mobli, Mehdi, Leffler, Andreas, Jiang, Daohua, Cox, James J., Waxman, Stephen G., Dib-Hajj, Sulayman D., Neely, G. Gregory, Durek, Thomas, Vetter, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147923/
https://www.ncbi.nlm.nih.gov/pubmed/37117223
http://dx.doi.org/10.1038/s41467-023-37963-2

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