In-vitro biological evaluation of 3,3′,5,5′-tetramethoxy-biphenyl-4,4′-diol and molecular docking studies on trypanothione reductase and Gp63 from Leishmania amazonensis demonstrated anti-leishmania potential

Available treatments for leishmaniasis have been widely used since the 1940s but come at a high cost, variable efficacy, high toxicity, and adverse side-effects. 3,3′,5,5′-Tetramethoxy-biphenyl-4,4′-diol (TMBP) was synthesized through laccase-catalysis of 2,6-dimethoxyphenol and displayed antioxidan...

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Detalles Bibliográficos
Autores principales: Schirmann, Jéseka G., Bortoleti, Bruna T. S., Gonçalves, Manoela D., Tomiotto-Pellissier, Fernanda, Camargo, Priscila G., Miranda-Sapla, Milena M., Lima, Camilo H. S., Bispo, Marcelle L. F., Costa, Idessania N., Conchon-Costa, Ivete, Pavanelli, Wander R., Dekker, Robert F. H., Barbosa-Dekker, Aneli M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147928/
https://www.ncbi.nlm.nih.gov/pubmed/37117253
http://dx.doi.org/10.1038/s41598-023-34124-9

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