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Heat shock protein: a double-edged sword linking innate immunity and hepatitis B virus infection

Heat shock proteins (HSPs), which have a variety of functions, are one of the stress protein families. In recent years, They have been reported to play a dual role in hepatitis B virus (HBV) which as persistent infection which is associated with, cirrhosis and liver cancer. In this article, we have...

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Detalles Bibliográficos
Autores principales: Dai, Wen-ying, Yao, Guo-qing, Deng, Xi-chuan, Zang, Guang-chao, Liu, Jia, Zhang, Guang-yuan, Chen, Yu-meng, Lv, Ming-qi, Chen, Ting-ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148040/
https://www.ncbi.nlm.nih.gov/pubmed/37128472
http://dx.doi.org/10.1016/j.jve.2023.100322
Descripción
Sumario:Heat shock proteins (HSPs), which have a variety of functions, are one of the stress protein families. In recent years, They have been reported to play a dual role in hepatitis B virus (HBV) which as persistent infection which is associated with, cirrhosis and liver cancer. In this article, we have summarized the regulatory mechanisms between HSPs and viruses, especially HBV and associated diseases based on HSP biological functions of in response to viral infections. In view of their potential as broad-spectrum antiviral targets, we have also discuss current progress and challenges in drug development based on HSPs, as well as the potential applications of agents that have been evaluated clinically in HBV treatment.