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Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease

BACKGROUND: The valine (branched-chain amino acid) metabolite 3-hydroxyisobutyrate (3-HIB), produced by 3-Hydroxyisobutyryl-CoA Hydrolase (HIBCH), is associated with insulin resistance and type 2 diabetes, but implicated tissues and cellular mechanisms are poorly understood. We hypothesized that HIB...

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Detalles Bibliográficos
Autores principales:	Bjune, Mona Synnøve, Lawrence-Archer, Laurence, Laupsa-Borge, Johnny, Sommersten, Cathrine Horn, McCann, Adrian, Glastad, Robert Clay, Johnston, Iain George, Kern, Matthias, Blüher, Matthias, Mellgren, Gunnar, Dankel, Simon N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148099/ https://www.ncbi.nlm.nih.gov/pubmed/37084480 http://dx.doi.org/10.1016/j.ebiom.2023.104569

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