Cargando…

Air pollution nanoparticle and alpha-synuclein fibrils synergistically decrease glutamate receptor A1, depending upon nPM batch activity

BACKGROUND: Epidemiological studies have variably linked air pollution to increased risk of Parkinson’s disease (PD). However, there is little experimental evidence for this association. Alpha-synuclein (α-syn) propagation plays central roles in PD and glutamate receptor A1 (GluA1) is involved in me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Hongqiao, D'Agostino, Carla, Tulisiak, Christopher, Thorwald, Max A., Bergkvist, Liza, Lindquist, Allison, Meyerdirk, Lindsay, Schulz, Emily, Becker, Katelyn, Steiner, Jennifer A., Cacciottolo, Mafalda, Kwatra, Mohit, Rey, Nolwen L., Escobar Galvis, Martha L., Ma, Jiyan, Sioutas, Constantinos, Morgan, Todd E., Finch, Caleb E., Brundin, Patrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148131/ https://www.ncbi.nlm.nih.gov/pubmed/37128335 http://dx.doi.org/10.1016/j.heliyon.2023.e15622

Ejemplares similares

NOVEL GAMMA-SECRETASE MODULATOR REGULATES APP PROCESSING AND INFLAMMATORY RESPONSES IN NPM-EXPOSED MICE
por: D'Agostino, Carla, et al.
Publicado: (2019)

T Cells Limit Accumulation of Aggregate Pathology Following Intrastriatal Injection of α-Synuclein Fibrils
por: George, Sonia, et al.
Publicado: (2021)

Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions
por: Haghani, Amin, et al.
Publicado: (2020)

Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease
por: George, Sonia, et al.
Publicado: (2019)

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb
por: Rey, Nolwen L., et al.
Publicado: (2019)

Diurnal variation in the proinflammatory activity of urban fine particulate matter (PM (2.5)) by in vitro assays
por: Lovett, Christopher, et al.
Publicado: (2018)

Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease
por: Graham, Stewart F., et al.
Publicado: (2018)

Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation
por: Mezias, Christopher, et al.
Publicado: (2019)

Loss of One Engrailed1 Allele Enhances Induced α-Synucleinopathy
por: Chatterjee, Diptaman, et al.
Publicado: (2019)

α‐Synuclein: The Long Distance Runner
por: George, Sonia, et al.
Publicado: (2013)

Deficits in olfactory sensitivity in a mouse model of Parkinson’s disease revealed by plethysmography of odor-evoked sniffing
por: Johnson, Michaela E., et al.
Publicado: (2020)

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice
por: Rey, Nolwen L., et al.
Publicado: (2013)

The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases
por: Rey, Nolwen L., et al.
Publicado: (2016)

Inflammation and α-Synuclein’s Prion-like Behavior in Parkinson's Disease—Is There a Link?
por: Lema Tomé, Carla M., et al.
Publicado: (2012)

SHORT-TERM DIESEL EXHAUST PARTICLE NEUROTOXICITY MEDIATED BY TLR4 ACROSS AGE AND SEX
por: Shkirkova, Kristina, et al.
Publicado: (2022)

Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala
por: Chen, Liqiang, et al.
Publicado: (2022)

HYPERTENSION DOES NOT CONTRIBUTE TO MICROBLEEDS ONSET IN FEMALE EFAD MICE
por: Cacciottolo, Mafalda, et al.
Publicado: (2019)

A novel automated morphological analysis of Iba1+ microglia using a deep learning assisted model
por: Stetzik, Lucas, et al.
Publicado: (2022)

The role of Galectin-3 in α-synuclein-induced microglial activation
por: Boza-Serrano, Antonio, et al.
Publicado: (2014)

Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term
por: Rey, Nolwen L., et al.
Publicado: (2017)

Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis
por: McDuff, Fiona Kate Elizabeth, et al.
Publicado: (2011)

Is the Enzyme ACMSD a Novel Therapeutic Target in Parkinson’s Disease?
por: Thirtamara-Rajamani, Keerthi, et al.
Publicado: (2017)

Immunotherapy in Parkinson’s Disease: Micromanaging Alpha-Synuclein Aggregation
por: George, Sonia, et al.
Publicado: (2015)

Magnetic resonance imaging of white matter response to diesel exhaust particles
por: Chakhoyan, Ararat, et al.
Publicado: (2023)

Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling
por: Okuwaki, Mitsuru, et al.
Publicado: (2012)

NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes
por: Darracq, Anaïs, et al.
Publicado: (2019)

Bone Marrow Clonogenic Myeloid Progenitors from NPM1-Mutated AML Patients Do Not Harbor the NPM1 Mutation: Implication for the Cell-Of-Origin of NPM1+ AML
por: Diaz de la Guardia, Rafael, et al.
Publicado: (2020)

Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease
por: Rey, Nolwen L., et al.
Publicado: (2016)

NPM-ALK-reactive T-cell responses in children and adolescents with NPM-ALK positive anaplastic large cell lymphoma
por: Singh, Vijay Kumar, et al.
Publicado: (2019)

Editorial: Targeting α-Synuclein in Parkinson's Disease and Multiple System Atrophy
por: Fellner, Lisa, et al.
Publicado: (2022)

Nucleophosmin1 (NPM1) abnormality in hematologic malignancies, and therapeutic targeting of mutant NPM1 in acute myeloid leukemia
por: Chen, Yingyu, et al.
Publicado: (2020)

Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
por: Fiskus, Warren, et al.
Publicado: (2022)

What’s to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?
por: Dunning, Christopher J.R., et al.
Publicado: (2013)

Characterization of Nanoparticle Batch-To-Batch Variability
por: Mülhopt, Sonja, et al.
Publicado: (2018)

Installing, maintaining, and publishing Node modules with npm
por: Powers, Shelley
Publicado: (2016)

Significance of NPM1 Gene Mutations in AML
por: Hindley, Andrew, et al.
Publicado: (2021)

The antagonistic duality of NPM1 mutations in AML
por: Khan, Irum, et al.
Publicado: (2022)

NPM 1 Mutations in AML—The Landscape in 2023
por: Sharma, Naman, et al.
Publicado: (2023)

The absent/low expression of CD34 in NPM1-mutated AML is not related to cytoplasmic dislocation of NPM1 mutant protein
por: Pianigiani, Giulia, et al.
Publicado: (2022)

Causal linkage of presence of mutant NPM1 to efficacy of novel therapeutic agents against AML cells with mutant NPM1
por: Mill, Christopher P., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ko6449u3mkaf1422ujb6tnchho