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Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation
Niemann-Pick disease type C (NP-C) is a genetic lysosomal disorder associated with progressive neurodegenerative phenotypes. Its therapeutic options are very limited. Here, we show that lithium treatment improves ataxia and feeding phenotypes, attenuates cerebellar inflammation and degeneration, and...
Autores principales: | Han, Shiqian, Wang, Qijun, Song, Yongfeng, Pang, Mao, Ren, Chunguang, Wang, Jing, Guan, Dongwei, Xu, Wei, Li, Fangyong, Wang, Fengchao, Zhou, Xinyuan, Fernández-Hernando, Carlos, Zhang, Huiwen, Wu, Dianqing, Ye, Zhijia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148154/ https://www.ncbi.nlm.nih.gov/pubmed/37128603 http://dx.doi.org/10.1016/j.isci.2023.106613 |
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