Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation

Niemann-Pick disease type C (NP-C) is a genetic lysosomal disorder associated with progressive neurodegenerative phenotypes. Its therapeutic options are very limited. Here, we show that lithium treatment improves ataxia and feeding phenotypes, attenuates cerebellar inflammation and degeneration, and...

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Detalles Bibliográficos
Autores principales: Han, Shiqian, Wang, Qijun, Song, Yongfeng, Pang, Mao, Ren, Chunguang, Wang, Jing, Guan, Dongwei, Xu, Wei, Li, Fangyong, Wang, Fengchao, Zhou, Xinyuan, Fernández-Hernando, Carlos, Zhang, Huiwen, Wu, Dianqing, Ye, Zhijia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148154/
https://www.ncbi.nlm.nih.gov/pubmed/37128603
http://dx.doi.org/10.1016/j.isci.2023.106613

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