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Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products

L1 is a dizinc subclass B3 metallo-β-lactamase (MBL) that hydrolyzes most β-lactam antibiotics and is a key resistance determinant in the Gram-negative pathogen Stenotrophomonas maltophilia, an important cause of nosocomial infections in immunocompromised patients. L1 is not usefully inhibited by MB...

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Detalles Bibliográficos
Autores principales:	Hinchliffe, Philip, Calvopiña, Karina, Rabe, Patrick, Mojica, Maria F., Schofield, Christopher J., Dmitrienko, Gary I., Bonomo, Robert A., Vila, Alejandro J., Spencer, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148155/ https://www.ncbi.nlm.nih.gov/pubmed/36924941 http://dx.doi.org/10.1016/j.jbc.2023.104606

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