Mechanism and linkage specificities of the dual retaining β-Kdo glycosyltransferase modules of KpsC from bacterial capsule biosynthesis

KpsC is a dual-module glycosyltransferase (GT) essential for “group 2” capsular polysaccharide biosynthesis in Escherichia coli and other Gram-negative pathogens. Capsules are vital virulence determinants in high-profile pathogens, making KpsC a viable target for intervention with small-molecule the...

Descripción completa

Detalles Bibliográficos
Autores principales: Doyle, Liam, Ovchinnikova, Olga G., Huang, Bo-Shun, Forrester, Taylor J.B., Lowary, Todd L., Kimber, Matthew S., Whitfield, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148158/
https://www.ncbi.nlm.nih.gov/pubmed/36924942
http://dx.doi.org/10.1016/j.jbc.2023.104609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148158/
https://www.ncbi.nlm.nih.gov/pubmed/36924942
http://dx.doi.org/10.1016/j.jbc.2023.104609

Ejemplares similares