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Mechanism and linkage specificities of the dual retaining β-Kdo glycosyltransferase modules of KpsC from bacterial capsule biosynthesis

KpsC is a dual-module glycosyltransferase (GT) essential for “group 2” capsular polysaccharide biosynthesis in Escherichia coli and other Gram-negative pathogens. Capsules are vital virulence determinants in high-profile pathogens, making KpsC a viable target for intervention with small-molecule the...

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Detalles Bibliográficos
Autores principales:	Doyle, Liam, Ovchinnikova, Olga G., Huang, Bo-Shun, Forrester, Taylor J.B., Lowary, Todd L., Kimber, Matthew S., Whitfield, Chris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148158/ https://www.ncbi.nlm.nih.gov/pubmed/36924942 http://dx.doi.org/10.1016/j.jbc.2023.104609

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