Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism

OBJECTIVE: Hepatic triacylglycerol accumulation and insulin resistance are key features of NAFLD. However, NAFLD development and progression are rather triggered by the aberrant generation of lipid metabolites and signaling molecules including diacylglycerol (DAG) and lysophosphatidylcholine (lysoPC...

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Detalles Bibliográficos
Autores principales: Chalhoub, Gabriel, Jamnik, Alina, Pajed, Laura, Kolleritsch, Stephanie, Hois, Victoria, Bagaric, Antonia, Prem, Dominik, Tilp, Anna, Kolb, Dagmar, Wolinski, Heimo, Taschler, Ulrike, Züllig, Thomas, Rechberger, Gerald N., Fuchs, Claudia, Trauner, Michael, Schoiswohl, Gabriele, Haemmerle, Guenter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148186/
https://www.ncbi.nlm.nih.gov/pubmed/37059417
http://dx.doi.org/10.1016/j.molmet.2023.101725

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