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Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors
Atherosclerosis is one of the most common types of cardiovascular disease and is driven by lipid accumulation and chronic inflammation in the arteries, which leads to stenosis and thrombosis. Researchers have been working to design multifunctional nanomedicines with the ability to target, diagnose,...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148422/ https://www.ncbi.nlm.nih.gov/pubmed/37118804 http://dx.doi.org/10.1186/s12951-023-01899-y |
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author | Chen, Siyu Su, Yuan Zhang, Manjin Zhang, Yulin Xiu, Peiming Luo, Wei Zhang, Qiuxia Zhang, Xinlu Liang, Hongbin Lee, Alex Pui-Wai Shao, Longquan Xiu, Jiancheng |
author_facet | Chen, Siyu Su, Yuan Zhang, Manjin Zhang, Yulin Xiu, Peiming Luo, Wei Zhang, Qiuxia Zhang, Xinlu Liang, Hongbin Lee, Alex Pui-Wai Shao, Longquan Xiu, Jiancheng |
author_sort | Chen, Siyu |
collection | PubMed |
description | Atherosclerosis is one of the most common types of cardiovascular disease and is driven by lipid accumulation and chronic inflammation in the arteries, which leads to stenosis and thrombosis. Researchers have been working to design multifunctional nanomedicines with the ability to target, diagnose, and treat atherosclerosis, but recent studies have also identified that nanomaterials can cause atherosclerosis. Therefore, this review aims to outline the molecular mechanisms and physicochemical properties of nanomaterials that promote atherosclerosis. By analyzing the toxicological effects of nanomaterials on cells involved in the pathogenesis of atherosclerosis such as vascular endothelial cells, vascular smooth muscle cells and immune cells, we aim to provide new perspectives for the prevention and treatment of atherosclerosis, and raise awareness of nanotoxicology to advance the clinical translation and sustainable development of nanomaterials. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-10148422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-101484222023-04-30 Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors Chen, Siyu Su, Yuan Zhang, Manjin Zhang, Yulin Xiu, Peiming Luo, Wei Zhang, Qiuxia Zhang, Xinlu Liang, Hongbin Lee, Alex Pui-Wai Shao, Longquan Xiu, Jiancheng J Nanobiotechnology Review Atherosclerosis is one of the most common types of cardiovascular disease and is driven by lipid accumulation and chronic inflammation in the arteries, which leads to stenosis and thrombosis. Researchers have been working to design multifunctional nanomedicines with the ability to target, diagnose, and treat atherosclerosis, but recent studies have also identified that nanomaterials can cause atherosclerosis. Therefore, this review aims to outline the molecular mechanisms and physicochemical properties of nanomaterials that promote atherosclerosis. By analyzing the toxicological effects of nanomaterials on cells involved in the pathogenesis of atherosclerosis such as vascular endothelial cells, vascular smooth muscle cells and immune cells, we aim to provide new perspectives for the prevention and treatment of atherosclerosis, and raise awareness of nanotoxicology to advance the clinical translation and sustainable development of nanomaterials. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2023-04-28 /pmc/articles/PMC10148422/ /pubmed/37118804 http://dx.doi.org/10.1186/s12951-023-01899-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Chen, Siyu Su, Yuan Zhang, Manjin Zhang, Yulin Xiu, Peiming Luo, Wei Zhang, Qiuxia Zhang, Xinlu Liang, Hongbin Lee, Alex Pui-Wai Shao, Longquan Xiu, Jiancheng Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors |
title | Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors |
title_full | Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors |
title_fullStr | Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors |
title_full_unstemmed | Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors |
title_short | Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors |
title_sort | insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148422/ https://www.ncbi.nlm.nih.gov/pubmed/37118804 http://dx.doi.org/10.1186/s12951-023-01899-y |
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