Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations

Loss of function progranulin (GRN) mutations are a major autosomal dominant cause of frontotemporal dementia (FTD). Patients with FTD due to GRN mutations (FTD-GRN) develop frontotemporal lobar degeneration with TDP-43 pathology type A (FTLD-TDP type A) and exhibit elevated levels of lysosomal prote...

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Detalles Bibliográficos
Autores principales: Davis, Skylar E., Cook, Anna K., Hall, Justin A., Voskobiynyk, Yuliya, Carullo, Nancy V., Boyle, Nicholas R., Hakim, Ahmad R., Anderson, Kristian M., Hobdy, Kierra P., Pugh, Derian A., Murchison, Charles F., McMeekin, Laura J., Simmons, Micah, Margolies, Katherine A., Cowell, Rita M., Nana, Alissa L., Spina, Salvatore, Grinberg, Lea T., Miller, Bruce L., Seeley, William W., Arrant, Andrew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148425/
https://www.ncbi.nlm.nih.gov/pubmed/37118844
http://dx.doi.org/10.1186/s40478-023-01571-4

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