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Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study
BACKGROUND: Considerable evidence has been reported that tobacco use could cause alterations in gut microbiota composition. The microbiota-gut–brain axis also in turn hinted at a possible contribution of the gut microbiota to smoking. However, population-level studies with a higher evidence level fo...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148467/ https://www.ncbi.nlm.nih.gov/pubmed/37118782 http://dx.doi.org/10.1186/s12916-023-02863-1 |
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author | Fan, Jiayao Zhou, Yuan Meng, Ran Tang, Jinsong Zhu, Jiahao Aldrich, Melinda C. Cox, Nancy J. Zhu, Yimin Li, Yingjun Zhou, Dan |
author_facet | Fan, Jiayao Zhou, Yuan Meng, Ran Tang, Jinsong Zhu, Jiahao Aldrich, Melinda C. Cox, Nancy J. Zhu, Yimin Li, Yingjun Zhou, Dan |
author_sort | Fan, Jiayao |
collection | PubMed |
description | BACKGROUND: Considerable evidence has been reported that tobacco use could cause alterations in gut microbiota composition. The microbiota-gut–brain axis also in turn hinted at a possible contribution of the gut microbiota to smoking. However, population-level studies with a higher evidence level for causality are lacking. METHODS: This study utilized the summary-level data of respective genome-wide association study (GWAS) for 211 gut microbial taxa and five smoking phenotypes to reveal the causal association between the gut microbiota and tobacco smoking. Two-sample bidirectional Mendelian randomization (MR) design was deployed and comprehensively sensitive analyses were followed to validate the robustness of results. We further performed multivariable MR to evaluate the effect of neurotransmitter-associated metabolites on observed associations. RESULTS: Our univariable MR results confirmed the effects of smoking on three taxa (Intestinimonas, Catenibacterium, and Ruminococcaceae, observed from previous studies) with boosted evidence level and identified another 13 taxa which may be causally affected by tobacco smoking. As for the other direction, we revealed that smoking behaviors could be potential consequence of specific taxa abundance. Combining with existing observational evidence, we provided novel insights regarding a positive feedback loop of smoking through Actinobacteria and indicated a potential mechanism for the link between parental smoking and early smoking initiation of their children driven by Bifidobacterium. The multivariable MR results suggested that neurotransmitter-associated metabolites (tryptophan and tyrosine, also supported by previous studies) probably played a role in the action pathway from the gut microbiota to smoking, especially for Actinobacteria and Peptococcus. CONCLUSIONS: In summary, the current study suggested the role of the specific gut microbes on the risk for cigarette smoking (likely involving alterations in metabolites) and in turn smoking on specific gut microbes. Our findings highlighted the hazards of tobacco use for gut flora dysbiosis and shed light on the potential role of specific gut microbiota for smoking behaviors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-023-02863-1. |
format | Online Article Text |
id | pubmed-10148467 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-101484672023-04-30 Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study Fan, Jiayao Zhou, Yuan Meng, Ran Tang, Jinsong Zhu, Jiahao Aldrich, Melinda C. Cox, Nancy J. Zhu, Yimin Li, Yingjun Zhou, Dan BMC Med Research Article BACKGROUND: Considerable evidence has been reported that tobacco use could cause alterations in gut microbiota composition. The microbiota-gut–brain axis also in turn hinted at a possible contribution of the gut microbiota to smoking. However, population-level studies with a higher evidence level for causality are lacking. METHODS: This study utilized the summary-level data of respective genome-wide association study (GWAS) for 211 gut microbial taxa and five smoking phenotypes to reveal the causal association between the gut microbiota and tobacco smoking. Two-sample bidirectional Mendelian randomization (MR) design was deployed and comprehensively sensitive analyses were followed to validate the robustness of results. We further performed multivariable MR to evaluate the effect of neurotransmitter-associated metabolites on observed associations. RESULTS: Our univariable MR results confirmed the effects of smoking on three taxa (Intestinimonas, Catenibacterium, and Ruminococcaceae, observed from previous studies) with boosted evidence level and identified another 13 taxa which may be causally affected by tobacco smoking. As for the other direction, we revealed that smoking behaviors could be potential consequence of specific taxa abundance. Combining with existing observational evidence, we provided novel insights regarding a positive feedback loop of smoking through Actinobacteria and indicated a potential mechanism for the link between parental smoking and early smoking initiation of their children driven by Bifidobacterium. The multivariable MR results suggested that neurotransmitter-associated metabolites (tryptophan and tyrosine, also supported by previous studies) probably played a role in the action pathway from the gut microbiota to smoking, especially for Actinobacteria and Peptococcus. CONCLUSIONS: In summary, the current study suggested the role of the specific gut microbes on the risk for cigarette smoking (likely involving alterations in metabolites) and in turn smoking on specific gut microbes. Our findings highlighted the hazards of tobacco use for gut flora dysbiosis and shed light on the potential role of specific gut microbiota for smoking behaviors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-023-02863-1. BioMed Central 2023-04-28 /pmc/articles/PMC10148467/ /pubmed/37118782 http://dx.doi.org/10.1186/s12916-023-02863-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Fan, Jiayao Zhou, Yuan Meng, Ran Tang, Jinsong Zhu, Jiahao Aldrich, Melinda C. Cox, Nancy J. Zhu, Yimin Li, Yingjun Zhou, Dan Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study |
title | Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study |
title_full | Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study |
title_fullStr | Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study |
title_full_unstemmed | Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study |
title_short | Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study |
title_sort | cross-talks between gut microbiota and tobacco smoking: a two-sample mendelian randomization study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148467/ https://www.ncbi.nlm.nih.gov/pubmed/37118782 http://dx.doi.org/10.1186/s12916-023-02863-1 |
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