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Overcoming translational barriers in H3K27-altered diffuse midline glioma: Increasing the drug-tumor residence time

BACKGROUND: H3K27-altered diffuse midline glioma (DMG) is the deadliest pediatric brain tumor; despite intensive research efforts, every clinical trial to date has failed. Is this because we are choosing the wrong drugs? Or are drug delivery and other pharmacokinetic variables at play? We hypothesiz...

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Detalles Bibliográficos
Autores principales:	Power, Erica A, Rechberger, Julian S, Zhang, Liang, Oh, Ju-Hee, Anderson, Jacob B, Nesvick, Cody L, Ge, Jizhi, Hinchcliffe, Edward H, Elmquist, William F, Daniels, David J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148679/ https://www.ncbi.nlm.nih.gov/pubmed/37128506 http://dx.doi.org/10.1093/noajnl/vdad033

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